Sapropterin dihydrochloride

 
National Institutes of Health

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2013
2013
BackgroundSapropterin dihydrochloride effectively lowers plasma phenylalanine (Phe) for at least a third of phenylketonuria (PKU… (More)
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2012
2012
UNLABELLED Sapropterin dihydrochloride, a synthetic tetrahydrobiopterin (BH4), works as a chaperone of phenylalanine hydroxylase… (More)
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2012
2012
Phenylketonuria (PKU) is an inherited disorder of phenylalanine (Phe) metabolism. Until recently, the only treatment for PKU was… (More)
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2011
2011
The authors investigated the safety of oral tetrahydrobiopterin (BH4), a cofactor for nitric oxide synthesis, as a novel… (More)
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2010
2010
Sapropterin dihydrochloride, a synthetic, stable form of the tetrahydrobiopterin cofactor of phenylalanine hydroxylase, has been… (More)
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Highly Cited
2009
Highly Cited
2009
OBJECTIVE To evaluate the ability of sapropterin dihydrochloride (pharmaceutical preparation of tetrahydrobiopterin) to increase… (More)
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2008
2008
Phenylketonuria (PKU) is an inherited metabolic disease characterized by phenylalanine (Phe) accumulation, which can lead to… (More)
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Highly Cited
2007
2007
2007
Methods We enrolled 89 patients with phenylketonuria in a Phase III, multicentre, randomised, double-blind, placebo-controlled… (More)
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Highly Cited
2007
Highly Cited
2007
SummaryThis study aimed to evaluate the response to and safety of an 8-day course of sapropterin dihydrochloride (6R… (More)
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