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Sapropterin

Known as: 6R-BH4, 6R-L-erythro-5,6,7,8-tetrahydrobiopterin, L-erythro-tetrahydrobiopterin 
National Institutes of Health

Related topics

Related topics

11 relations
2,4,5-trihydroxybutyrophenoneBreast Cancer Resistance Protein Inhibitors [MoA]Sapropterin dihydrochlorideSapropterin dihydrochloride 100 MG Oral Tablet [Kuvan]

Broader (2)

Biopterinpteridine analog

Narrower (2)

D-threo-tetrahydrobiopterinKuvan

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
A reply to ‘Metabolic effects of sapropterin treatment in autism spectrum disorder: a preliminary study'
Frye et al.1 published a study in Translational Psychiatry that indicated that treatment with sapropterin, which is a synthetic… 
2016
2016
Evaluation of Tetrahydrobiopterin Therapy with Large Neutral Amino Acid Supplementation in Phenylketonuria: Effects on Potential Peripheral Biomarkers, Melatonin and Dopamine, for Brain Monoamine…
Background Phenylketonuria (PKU) is due to a defective hepatic enzyme, phenylalanine (Phe) hydroxylase. Transport of the… 
Review
2015
Review
2015
Minimally invasive (13)C-breath test to examine phenylalanine metabolism in children with phenylketonuria.
2013
2013
A Pilot Study of Fluorodeoxyglucose Positron Emission Tomography Findings in Patients with Phenylketonuria before and during Sapropterin Supplementation
Background and Purpose PET scanning with fluorodeoxyglucose (FDG-PET) is a non-invasive method that measures regional glucose… 
Highly Cited
2010
Highly Cited
2010
Sapropterin therapy increases stability of blood phenylalanine levels in patients with BH4-responsive phenylketonuria (PKU).
2005
2005
Effects of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin on the dopaminergic and cholinergic receptors as evaluated by positron emission tomography in the Rhesus monkey
The effects of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (R-THBP) on the central cholinergic and dopaminergic systems in the… 
1996
1996
Repeated peripheral administration of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin alters the binding activities of 5-HT1A and 5-HT2 receptors in rat brain.
Repeated peripheral administration of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (R-THBP) induced significant changes in the… 
1992
1992
Assessment of the ambulation-increasing effect of ketamine by coadministration with central-acting drugs in mice.
The coadministration of ketamine (12.5 mg/kg, but not 3.1 mg/kg, s.c.) with methamphetamine (2 mg/kg, s.c.), cocaine (10 mg/kg, s… 
1989
1989
Enhancement of ambulation-increasing effect of methamphetamine by peripherally-administered 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (R-THBP) in mice.
Behavioral effects of 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (R-THBP), a co-factor for tyrosine hydroxylase and tryptophan… 
1971
1971
6-Methyltetrahydropterin. Isolation and identification as the highly active hydroxylase cofactor from tetrahydrofolate.
A purification of freshly reduced tetrahydrofolate by column chromatography has resulted in the separation of the more active… 
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