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STX11 gene

Known as: STX11, SYNTAXIN 11, Syntaxin 11 Gene 
This gene plays a role in the targeting and fusion of intracellular transport vesicles.
National Institutes of Health

Related topics

Related topics

7 relations
Homo sapiensIntracellular TransportLigand BindingMolecular Transport

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Bi-Allelic Mutations in STXBP2 Reveal a Complementary Role for STXBP1 in Cytotoxic Lymphocyte Killing
The ability of cytotoxic lymphocytes (CL) to eliminate virus-infected or cancerous target cells through the granule exocytosis… 
Review
2015
Review
2015
Prognostic Factors and Long-Term Outcome in 52 Turkish Children With Hemophagocytic Lymphohistiocytosis*
Objectives: Hemophagocytic lymphohistiocytosis is a syndrome of pathologic immune activation that shares similar clinical and… 
2015
2015
Munc18‐2 is required for Syntaxin 11 Localization on the Plasma Membrane in Cytotoxic T‐Lymphocytes
Cytotoxic T‐lymphocytes (CTL) kill their targets by cytolytic granule secretion at the immunological synapse. The Sec/Munc… 
2015
2015
STX11 functions as a novel tumor suppressor gene in peripheral T-cell lymphomas
Peripheral T‐cell lymphomas (PTCL) are a heterogeneous group of non‐Hodgkin lymphomas with poor prognosis. Their molecular… 
2014
2014
Analysis of Familial Hemophagocytic Lymphohistiocytosis Type 4 (FHL-4) Mutant Proteins Reveals that S-Acylation Is Required for the Function of Syntaxin 11 in Natural Killer Cells
Natural killer (NK) cell secretory lysosome exocytosis and cytotoxicity are impaired in familial hemophagocytic… 
2013
2013
An N-Terminal Missense Mutation in STX11 Causative of FHL4 Abrogates Syntaxin-11 Binding to Munc18-2
Familial hemophagocytic lymphohistiocytosis (FHL) is an often-fatal hyperinflammatory disorder caused by autosomal recessive… 
2011
2011
Hemophagocytic lymphohistiocytosis with MUNC13‐4 gene mutation or reduced natural killer cell function prior to onset of childhood leukemia
Hemophagocytic lymphohistiocytosis (HLH) is a rare histiocytic reactive process due to mutations in the perforin, MUNC13‐4 or… 
Review
2011
Review
2011
Advances in Hemophagocytic Lymphohistiocytosis: Pathogenesis, Early Diagnosis/Differential Diagnosis, and Treatment
Hemophagocytic lymphohistiocytosis (HLH) is a histiocytic disorder characterized by a highly stimulated, but ineffective, immune… 
Highly Cited
2010
Highly Cited
2010
STXBP2 mutations in children with familial haemophagocytic lymphohistiocytosis type 5
Background Familial haemophagocytic lymphohistiocytosis (FHL) is a rare immune deficiency with uncontrolled inflammation; the… 
Highly Cited
2005
Highly Cited
2005
Spectrum and clinical implications of syntaxin 11 gene mutations in familial haemophagocytic lymphohistiocytosis: association with disease-free remissions and haematopoietic malignancies
Objective: To determine the frequency and spectrum of mutations in the gene encoding syntaxin 11 (STX11) in familial… 
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