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STAT6 gene

Known as: STAT6c, STAT6/NAB2 FUSION GENE, STAT6 
This gene plays a role in signal transduction and activation of transcription.
National Institutes of Health

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Homo sapiensNAB2 geneSTAT6 Transcription FactorSTAT6 protein, human

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STAT6 wt Allele

Papers overview

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2011
2011
IL-4 and IL-13 suppress prostaglandins production in human follicular dendritic cells by repressing COX-2 and mPGES-1 expression through JAK1 and STAT6.
Highly Cited
2009
Highly Cited
2009
Small Interfering RNA against Transcription Factor STAT6 Inhibits Allergic Airway Inflammation and Hyperreactivity in Mice1
In the context of allergic immune responses, activation of STAT6 is pivotal for Th2-mediated IgE production and development of… 
Highly Cited
2004
Highly Cited
2004
The Transcriptional Co-activator p/CIP (NCoA-3) Is Up-regulated by STAT6 and Serves as a Positive Regulator of Transcriptional Activation by STAT6*
Transcriptional activation by signal transducer and activator of transcription 6 (STAT6) has been shown to require the direct… 
Highly Cited
2002
Highly Cited
2002
Cutting Edge: STAT6 Serves as a Positive and Negative Regulator of Gene Expression in IL-4-Stimulated B Lymphocytes1
STAT6 plays an important role in IL-4-mediated B cell activation and differentiation. To identify primary and secondary target… 
Highly Cited
2001
Highly Cited
2001
TH2 cytokine-associated transcription factors in atopic and nonatopic asthma: evidence for differential signal transducer and activator of transcription 6 expression.
BACKGROUND The expression of IL-4 and IL-5 is increased in patients with atopic asthma compared with control subjects and… 
Highly Cited
1999
Highly Cited
1999
IL-4 inhibits the production of TNF-alpha and IL-12 by STAT6-dependent and -independent mechanisms.
IL-4 promotes allergic responses and inhibits the production of proinflammatory cytokines by monocytes and macrophages. The… 
Highly Cited
1999
Highly Cited
1999
Inhibition of Kit expression by IL-4 and IL-10 in murine mast cells: role of STAT6 and phosphatidylinositol 3'-kinase.
The c-kit protooncogene encodes a receptor tyrosine kinase that is known to play a critical role in hemopoiesis and is essential… 
Highly Cited
1997
Highly Cited
1997
Identification of a STAT6 domain required for IL-4-induced activation of transcription.
Tyrosine phosphorylation of STAT6 in response to IL-4 results in the formation of STAT6 homodimers that bind specific DNA… 
Highly Cited
1997
Highly Cited
1997
Interleukin-4 suppression of tumor necrosis factor alpha-stimulated E-selectin gene transcription is mediated by STAT6 antagonism of NF-kappaB.
Interleukin-4 (IL-4), an immunoregulatory cytokine secreted from activated T-helper 2 lymphocytes, eosinophils, and mast cells… 
Highly Cited
1996
Highly Cited
1996
IL-4-induced expression of the IL-1 receptor antagonist gene is mediated by STAT6.
IL-4 alone or in cooperation with LPS can induce the expression of the gene encoding the secreted-type IL-1 receptor antagonist… 
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