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STAT1 wt Allele

Known as: ISGF-3, STAT91, Signal Transducer and Activator of Transcription 1, 91kDa wt Allele 
Human STAT1 wild-type allele is located within 2q32.2-q32.3 and is approximately 45 kb in length. This allele, which encodes signal transducer and… Expand
National Institutes of Health

Related topics

Related topics

20 relations
2q32.2EGF Signaling PathwayErythropoietin Signaling PathwayHomo sapiens
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Broader (1)

STAT1 gene

Papers overview

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Highly Cited
1995
Highly Cited
1995
Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses.
Genes containing the interferon-stimulated response element (ISRE) enhancer have been characterized as transcriptionally… Expand
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Highly Cited
1994
Highly Cited
1994
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6.
The STAT family of proteins carries out a dual function: signal transduction and activation of transcription. A new family member… Expand
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Highly Cited
1994
Highly Cited
1994
Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine.
Concentration of urine in mammals is regulated by the antidiuretic hormone vasopressin. Binding of vasopressin to its V2 receptor… Expand
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Highly Cited
1994
Highly Cited
1994
Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions
Stat91 (a 91 kd protein that acts as a signal transducer and activator of transcription) is inactive in the cytoplasm of… Expand
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Highly Cited
1994
Highly Cited
1994
The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family.
Interleukin-6 (IL-6), leukemia inhibitory factor, oncostatin M, IL-11, and ciliary neurotropic factor are a family of cytokines… Expand
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1994
1994
Rapid changes in nuclear protein tyrosine phosphorylation after growth hormone treatment in vivo. Identification of phosphorylated mitogen-activated protein kinase and STAT91.
Growth hormone (GH) plays a central role in regulating growth and intermediary metabolism in vertebrates, although the mechanisms… Expand
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Highly Cited
1993
Highly Cited
1993
A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma.
Interferon-gamma (IFN-gamma) stimulates transcription of specific genes by inducing tyrosine phosphorylation of a 91-kilodalton… Expand
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Highly Cited
1993
Highly Cited
1993
Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins
BINDING of interferons IFN-α and IFN-γ to their cell surface receptors promptly induces tyrosine phosphorylation of latent… Expand
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Highly Cited
1991
Highly Cited
1991
Two distinct alpha-interferon-dependent signal transduction pathways may contribute to activation of transcription of the guanylate-binding protein gene.
The promoter of the gene encoding a cytoplasmic guanylate-binding protein (GBP) contains two overlapping elements: the interferon… Expand
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1989
1989
Differential binding of interferon-induced factors to an oligonucleotide that mediates transcriptional activation.
Type I interferons elicit a number of biological responses by rapidly and transiently stimulating the transcriptional expression… Expand
  • figure 1
  • table 1
  • figure 2
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  • figure 4
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