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STA-1474

National Institutes of Health

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2018
2018
Consecutive Day HSP90 Inhibitor Administration Improves Efficacy in Murine Models of KIT-Driven Malignancies and Canine Mast Cell Tumors
Purpose: STA-1474, prodrug of the heat shock protein 90 inhibitor (HSP90i) ganetespib, previously demonstrated activity in canine… 
2015
2015
Human Genetic Relevance and Potent Antitumor Activity of Heat Shock Protein 90 Inhibition in Canine Lung Adenocarcinoma Cell Lines
Background It has been an open question how similar human and canine lung cancers are. This has major implications in… 
2013
2013
Abstract 3369: The importance of dose schedule with Hsp90 inhibitors: Results from a Phase II study in dogs with mast cell tumors.
Purpose: STA-1474 is the prodrug of ganetespib, currently the most advanced Hsp90 inhibitor in human clinical trials. In a Phase… 
2013
2013
Analysis of HSP90 and HSP70 expression in dogs before and after treatment with STA-1474.
2011
2011
Abstract 1282: Phase I evaluation of STA-1474, a pro-drug of the novel HSP90 inhibitor STA-9090, in dogs with spontaneous cancer
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL The novel water soluble compound STA-1474 is… 
2011
2011
Investigating the Biological and Biochemical Consequences of Met Function and Dysfunction in Canine Osteosarcoma
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