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Translational control depends on phosphorylation of eIF2α by PKR-like ER kinase (PERK). To examine the role of PERK in cognitive… Expand Glycine transporter-1 (GlyT-1) in glial cells regulates extracellular levels of glycine, which acts as an obligatory co-agonist… Expand Conditioned stress-induced freezing has been used as an indicator of anxiety in rodents to evaluate the anxiolytic effects of… Expand The specific glycine transporter 1 (GlyT1) inhibitor, SSR504734, is highly effective in enhancing N-methyl-D-aspartate receptor… Expand RationaleInhibition of the glycine transporter 1 (GlyT1) activity increases extra-cellular glycine availability in the CNS. At… Expand RationaleSSR103800 and SSR504734 are novel glycine transport 1 (GlyT1) inhibitors with therapeutic potential for the treatment of… Expand RationaleIncreasing experimental evidence suggests that impaired N-methyl-d-aspartic acid (NMDA) receptor (NMDAr) function could… Expand In the forebrain, synaptic glycine concentrations are regulated through the glycine transporter GlyT1. Because glycine is a… Expand 2-Chloro-N-S-phenyl 2S-piperidin-2-yl methyl]-3-trifluoromethyl benzamide, monohydrochloride (SSR504734) is a potent and… Expand Noncompetitive N-methyl-D-aspartate (NMDA) blockers induce schizophrenic-like symptoms in humans, presumably by impairing… Expand