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SRM gene

Known as: SPERMIDINE SYNTHASE, SPS1, SRM 
National Institutes of Health

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Spermidine Synthase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Structural insights into the novel inhibition mechanism of Trypanosoma cruzi spermidine synthase.
Trypanosoma cruzi causes Chagas disease, a severe disease affecting 8-10 million people in Latin America. While nifurtimox and… 
2010
2010
Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels
BackgroundPlasmodium falciparum, the causative agent of severe human malaria, has evolved to become resistant to previously… 
Highly Cited
2009
Highly Cited
2009
RNA Interference-Mediated Silencing of Ornithine Decarboxylase and Spermidine Synthase Genes in Trypanosoma brucei Provides Insight into Regulation of Polyamine Biosynthesis
ABSTRACT Polyamine biosynthesis is a drug target for the treatment of African sleeping sickness; however, mechanisms regulating… 
2009
2009
Microarray studies on the genes responsive to the addition of spermidine or spermine to a Saccharomyces cerevisiae spermidine synthase mutant
The naturally occurring polyamines putrescine, spermidine or spermine are ubiquitous in all cells. Although polyamines have… 
Highly Cited
2004
Highly Cited
2004
A distinctive class of spermidine synthase is involved in chilling response in rice.
2004
2004
Organization of the MASP2 locus and its expression profile in mouse and rat
The mouse, rat, and human MASP2 loci are situated on syntenic chromosome regions and are highly conserved. They comprise the… 
Highly Cited
1998
Highly Cited
1998
Molecular cloning of plant spermidine synthases.
Four cDNAs for spermidine synthase (SPDS), which converts the diamine putrescine to the higher polyamine spermidine using… 
1997
1997
Transgenic mice overexpressing ornithine and S-adenosylmethionine decarboxylases maintain a physiological polyamine homoeostasis in their tissues.
Recent work has shown that transgenic mice overexpressing human ornithine decarboxylase display no marked changes in the tissue… 
1982
1982
Purification of spermidine synthase from rat ventral prostate by affinity chromatography on immobilized S-adenosyl(5')-3-thiopropylamine.
Highly Cited
1980
Highly Cited
1980
Dicyclohexylamine, a potent inhibitor of spermidine synthase in mammalian cells
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