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Severe Hypercholesterolemia, Hypertriglyceridemia, and Atherosclerosis in Mice Lacking Both Leptin and the Low Density Lipoprotein Receptor*
Leptin-deficient mice (ob/ob) are an excellent murine model for obesity, insulin resistance, and diabetes, all of which are components of a multiple risk factor syndrome that, along withExpand
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Phenochalasins, inhibitors of lipid droplet formation in mouse macrophages, produced by Phomopsis sp. FT-0211.
Phomopsis sp. FT-0211, a soil isolate, was found to produce inhibitors of lipid droplet formation in mouse peritoneal macrophages. Structurally related new compounds designated phenochalasins A and BExpand
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Structure elucidation of fungal phenochalasins, novel inhibitors of lipid droplet formation in mouse macrophages.
The structures of phenochalasins A and B were elucidated by spectroscopic studies including various NMR measurements. Phenochalasins A and B have the cytochalasan skeleton of the 21,23-dioxa,Expand
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Antiatherogenic activity of fungal beauveriolides, inhibitors of lipid droplet accumulation in macrophages.
Beauveriolides I and III, isolated from the culture broth of fungal Beauveria sp. FO-6979, showed potent inhibitory activity of lipid droplet accumulation in primary mouse peritoneal macrophages. TheExpand
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Complete inhibition of mouse macrophage-derived foam cell formation by triacsin C.
Primary mouse peritoneal macrophages effectively take up and metabolize phosphatidylcholine/cholesterol liposomes containing a small amount of phosphatidylserine, which results in the massiveExpand
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Enhanced antitumor activity of xanthohumol, a diacylglycerol acyltransferase inhibitor, under hypoxia.
Cancer chemotherapy for hypoxic tumor cells is thought to be an important issue, since hypoxia is related to tumor growth, apoptosis, angiogenesis and metastasis. Here, the bioactivities ofExpand
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Structure-specific inhibition of cholesteryl ester transfer protein by azaphilones.
The effect of thirteen different fungal azaphilones, which have a common 6-iso-chromane-like ring, was tested on cholesteryl ester transfer protein (CETP) activity in vitro. Chaetoviridin B showedExpand
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Sespendole, a New Inhibitor of Lipid Droplet Synthesis in Macrophages, Produced by Pseudobotrytis terrestris FKA-25
Sespendole was isolated as an inhibitor of lipid droplet formation in macrophages from the culture broth of a fungal strain Pseudobotrytis terrestris FKA-25. The compound inhibited the synthesis ofExpand
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Microbial metabolites with inhibitory activity against lipid metabolism
Microbial products inhibiting lipid metabolism, particularly involved in the fatty acid and cholesterol metabolic pathways were screened with various assay systems. Inhibitors were discovered forExpand
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Molecular target of decursins in the inhibition of lipid droplet accumulation in macrophages.
During screening for inhibitors of lipid droplet accumulation in mouse peritoneal macrophages, two coumarins identified as decursin and decursinol angelate were isolated from the roots of AngelicaeExpand
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