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SR 13668

Known as: SR-13668, SR13668 
National Institutes of Health

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1 relation

Broader (1)

Carbazoles

Papers overview

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2013
2013
Enhanced oral bioavailability of the hydrophobic chemopreventive agent (SR13668) in beagle dogs.
Potency and activity of SR13668 in cancer prevention have been proven in several in vitro and in vivo cancer models. However, the… 
2012
2012
Enhanced oral bioavailability of a cancer preventive agent (SR13668) by employing polymeric nanoparticles with high drug loading.
SR13668 [2,10-Dicarbethoxy-6-methoxy-5,7-dihydro-indolo-(2,3-b)carbazole] has been proven effective in cancer prevention, but the… 
2011
2011
Phase 0 Clinical Chemoprevention Trial of the Akt Inhibitor SR13668
SR13668, an orally active Akt pathway inhibitor, has demonstrated cancer chemopreventive potential in preclinical studies. To… 
2011
2011
Improved oral bioavailability in rats of SR13668, a novel anti-cancer agent
PurposeSR13668, a bis-indole with potent activity in vitro and in vivo against various cancers and promising cancer… 
2010
2010
Pharmacokinetics and enhanced bioavailability of candidate cancer preventative agent, SR13668 in dogs and monkeys
PurposeSR13668 (2,10-dicarbethoxy-6-methoxy-5,7-dihydro-indolo-(2,3-b)carbazole), is a new candidate cancer chemopreventive agent… 
2010
2010
Abstract CN02-03: Phase 0 chemoprevention trial of SR13668, a novel AKT inhibitor, in normal volunteers
Purpose: SR13668, an orally active AKT pathway inhibitor, has demonstrated cancer chemopreventive potential in preclinical… 
2009
2009
In vitro assessment of P450 induction potential of novel chemopreventive agents SR13668, 9-cis-UAB30, and pentamethychromanol in primary cultures of human hepatocytes.
Highly Cited
2007
Highly Cited
2007
Computer-aided rational drug design: a novel agent (SR13668) designed to mimic the unique anticancer mechanisms of dietary indole-3-carbinol to block Akt signaling.
Indole-3-carbinol (I3C) is a naturally occurring anticancer agent and has entered clinical trials for cancer prevention. However… 
2007
2007
Evaluation of chemopreventive agents for genotoxic activity.
2006
2006
Signaling-transduction pathways required for ex vivo expansion of human limbal explants on intact amniotic membrane.
PURPOSE Ex vivo expansion of limbal epithelial progenitor cells on amniotic membrane (AM) without 3T3 fibroblasts is a new… 
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