SQSTM1 gene

Known as: A170, P62, UBIQUITIN-BINDING PROTEIN P62 
This gene is involved in signal transduction.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
OBJECTIVE There is increasing evidence that common genetic risk factors underlie frontotemporal lobar degeneration (FTLD) and… (More)
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Highly Cited
2012
Highly Cited
2012
Although p62/SQSTM1 was initially identified as an essential mediator of NFκB signaling, several recent studies have also… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND The SQSTM1 gene encodes p62, a major pathologic protein involved in neurodegeneration. OBJECTIVE To examine whether… (More)
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Highly Cited
2011
Highly Cited
2011
Selective macroautophagy (autophagy) of ubiquitinated protein is implicated as a compensatory mechanism of the ubiquitin… (More)
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Highly Cited
2010
Highly Cited
2010
The p62/SQSTM1 (sequestosome 1) protein, which acts as a cargo receptor for autophagic degradation of ubiquitinated targets, is… (More)
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Highly Cited
2010
Highly Cited
2010
Mitochondria sustain damage with aging, and the resulting mitochondrial dysfunction has been implicated in a number of diseases… (More)
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Highly Cited
2010
Highly Cited
2010
PINK1 and Parkin were first identified as the causal genes responsible for familial forms of early-onset Parkinson's disease (PD… (More)
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Highly Cited
2009
Highly Cited
2009
Autophagy, a cellular degradative pathway, plays a key role in protecting the cytosol from bacterial colonization, but the… (More)
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Highly Cited
2005
Highly Cited
2005
Autophagic degradation of ubiquitinated protein aggregates is important for cell survival, but it is not known how the autophagic… (More)
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Highly Cited
2002
Highly Cited
2002
Paget's disease of bone (PDB) is a common disorder characterized by focal abnormalities of increased and disorganized bone… (More)
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