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SPRY2 wt Allele

Known as: Sprouty Homolog 2 (Drosophila) wt Allele, hSPRY2 
Human SPRY2 wild-type allele is located in the vicinity of 13q31.1 and is approximately 5 kb in length. This allele, which encodes protein sprouty… 
National Institutes of Health

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Signal TransductionSignal Transduction Inhibition

Papers overview

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2017
2017
[Establishment of a human bladder cancer cell line stably co-expressing hSPRY2 and luciferase genes and its subcutaneous tumor xenograft model in nude mice].
Objective To establish a human bladder cancer cell line stably co-expressing human sprouty2 (hSPRY2) and luciferase (Luc) genes… 
2014
2014
[Over-expression of human SPRY2 promotes the proliferation and survival of HEK293T cells].
OBJECTIVE To construct a recombinant expression vector pDC315/hSPRY2 carrying human SPRY2 (hSPRY2) gene, and transfect the… 
2008
2008
A Novel Role of Sprouty 2 in Regulating Cellular Apoptosis*
Sprouty (SPRY) proteins modulate receptor-tyrosine kinase signaling and, thereby, regulate cell migration and proliferation. Here… 
2008
2008
Epigenetic inactivation of the ERK inhibitor Spry2 in B-cell diffuse lymphomas
Spry2 has been characterized as a negative regulator of the extracellular-regulated kinase (ERK) pathway. In this study we… 
Highly Cited
2006
Highly Cited
2006
The Tumor Suppressor PTEN Is Necessary for Human Sprouty 2-mediated Inhibition of Cell Proliferation*
Sprouty family proteins are novel regulators of growth factor actions. Human Sprouty 2 (hSPRY2) inhibits the proliferation of a… 
Highly Cited
2005
Highly Cited
2005
Regulation of Vascular Smooth Muscle Cell Proliferation and Migration by Human Sprouty 2
Objectives—To determine whether the human sprouty 2 (hSPRY2) protein, an inhibitor of receptor tyrosine kinase actions, regulates… 
2003
2003
Protein-tyrosine Phosphatase-1B (PTP1B) Mediates the Anti-migratory Actions of Sprouty*
Mammalian Sprouty proteins have been shown to inhibit the proliferation and migration of cells in response to growth factors and… 
2003
2003
Nucleoli come undone
![Graphic][1] A nucleolar protein (red) disperses upon addition of FRGY2a (right). Kikyo/MacmillanThe nucleolus is essential… 
Highly Cited
2001
Highly Cited
2001
The C Terminus of Sprouty Is Important for Modulation of Cellular Migration and Proliferation*
The Drosophila Sprouty (SPRY) protein has been shown to inhibit the actions of epidermal growth factor and fibroblast growth… 
Highly Cited
2001
Highly Cited
2001
Evidence for Direct Interaction between Sprouty and Cbl*
Sprouty (SPRY) was first identified in a genetic screen in Drosophila as an antagonist of fibroblast and epidermal growth factor… 
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