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SPR gene

Known as: SDR38C1, SPR, SEPIAPTERIN REDUCTASE 
 
National Institutes of Health

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Sepiapterin reductase

Papers overview

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2015
2015
Effect of sulfasalazine on human neuroblastoma: analysis of sepiapterin reductase (SPR) as a new therapeutic target
BackgroundNeuroblastoma (NB) is an aggressive childhood malignancy in children up to 5 years of age. High-stage tumors frequently… Expand
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2009
2009
Polymorphisms of sepiapterin reductase gene alter promoter activity and may influence risk of bipolar disorder.
OBJECTIVES In a previous investigation, we observed altered expression of sepiapterin reductase (SPR) in cultured neural cells… Expand
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2008
2008
Proteomic analysis of embryonic stem cell-derived neural cells exposed to the antidepressant paroxetine.
Antidepressant drugs can have significant effects on the mood of a patient suffering from major depression or other disorders… Expand
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2006
2006
The zebrafish mutation m865 affects formation of dopaminergic neurons and neuronal survival, and maps to a genetic interval containing the sepiapterin reductase locus
The zebrafish mutation m865 was isolated during a large-scale mutagenesis screen aimed at identifying genes involved in the… Expand
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2005
2005
The sepiapterin reductase gene region reveals association in the PARK3 locus: analysis of familial and sporadic Parkinson's disease in European populations.
BACKGROUND Parkinson's disease is a genetically complex disease with mixed mode of inheritance. Recently, a haplotype across the… Expand
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2004
2004
Heterozygous mutation in 5’-untranslated region of sepiapterin reductase gene (SPR) in a patient with dopa-responsive dystonia
Abstract.The search for mutations in genes coding for components of the biopterin pathway other than GTPCH1 revealed a mutation… Expand
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2000
2000
Characterization of recombinant Dictyostelium discoideum sepiapterin reductase expressed in E. coli.
A cDNA clone (SSC801) putatively encoding sepiapterin reductase (SR) was obtained from the expressed sequence tag clones of… Expand
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2000
2000
Structure, chromosomal localization, and expression of the Drosophila melanogaster gene encoding sepiapterin reductase.
We have isolated and characterized a Drosophila melanogaster gene encoding the sepiapterin reductase (SR). The gene does not have… Expand
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1993
1993
Detection of a novel sepiapterin reductase mRNA: assay of mRNA in various cells and tissues of various species.
Fragments of cDNA coding for rat, murine, and human sepiapterin reductase (SR) were amplified by PCR via primer positioning close… Expand
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1984
1984
Sepiapterin reductase exhibits a NADPH-dependent dicarbonyl reductase activity.
We have found a new ability of sepiapterin reductase, which has been known to show a strict substrate specificity for the 6… Expand
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