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SPR gene

Known as: SDR38C1, SPR, SEPIAPTERIN REDUCTASE 
National Institutes of Health

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Sepiapterin reductase

Papers overview

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2019
2019
Sepiapterin Reductase Inhibition Leading to Selective Reduction of Inflammatory Joint Pain in Mice and Increased Urinary Sepiapterin Levels in Humans and Mice
To evaluate the antiinflammatory and analgesic effects of sepiapterin reductase (SPR) inhibition in a mouse model of inflammatory… 
2015
2015
Effect of sulfasalazine on human neuroblastoma: analysis of sepiapterin reductase (SPR) as a new therapeutic target
BackgroundNeuroblastoma (NB) is an aggressive childhood malignancy in children up to 5 years of age. High-stage tumors frequently… 
2009
2009
Polymorphisms of sepiapterin reductase gene alter promoter activity and may influence risk of bipolar disorder
Objectives In a previous investigation, we observed altered expression of sepiapterin reductase (SPR) in cultured neural cells… 
2008
2008
Proteomic analysis of embryonic stem cell–derived neural cells exposed to the antidepressant paroxetine
Antidepressant drugs can have significant effects on the mood of a patient suffering from major depression or other disorders… 
Highly Cited
2006
Highly Cited
2006
The sepiapterin reductase gene region reveals association in the PARK3 locus: analysis of familial and sporadic Parkinson’s disease in European populations
Background: Parkinson’s disease is a genetically complex disease with mixed mode of inheritance. Recently, a haplotype across the… 
Highly Cited
2004
Highly Cited
2004
Heterozygous mutation in 5’-untranslated region of sepiapterin reductase gene (SPR) in a patient with dopa-responsive dystonia
Abstract.The search for mutations in genes coding for components of the biopterin pathway other than GTPCH1 revealed a mutation… 
2000
2000
Characterization of recombinant Dictyostelium discoideum sepiapterin reductase expressed in E. coli.
A cDNA clone (SSC801) putatively encoding sepiapterin reductase (SR) was obtained from the expressed sequence tag clones of… 
1998
1998
Isolation and characterization of the Drosophila melanogaster cDNA encoding the sepiapterin reductase.
1993
1993
Detection of a novel sepiapterin reductase mRNA: assay of mRNA in various cells and tissues of various species.
Fragments of cDNA coding for rat, murine, and human sepiapterin reductase (SR) were amplified by PCR via primer positioning close… 
1984
1984
Sepiapterin reductase exhibits a NADPH-dependent dicarbonyl reductase activity.
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