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SPAM1 wt Allele
Known as:
HYA1
, MGC26532
, SPAG15
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Human SPAM1 wild-type allele is located in the vicinity of 7q31.3 and is approximately 46 kb in length. This allele, which encodes hyaluronidase PH…
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National Institutes of Health
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Related topics
Related topics
7 relations
7q31.3
Carbohydrate Metabolism
Cell Adhesion
Fertilization
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Broader (1)
SPAM1 gene
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization
G. Kondoh
,
H. Tojo
,
+8 authors
J. Takeda
Nature Medicine
2005
Corpus ID: 25149660
The angiotensin-converting enzyme (ACE) is a key regulator of blood pressure. It is known to cleave small peptides, such as…
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Highly Cited
2002
Highly Cited
2002
Mouse Sperm Lacking Cell Surface Hyaluronidase PH-20 Can Pass through the Layer of Cumulus Cells and Fertilize the Egg*
Daichi Baba
,
S. Kashiwabara
,
+5 authors
T. Baba
The Journal of Biological Chemistry
2002
Corpus ID: 20099560
The function of glycosylphosphatidylinositol-anchored sperm hyaluronidase PH-20 in fertilization has long been believed to enable…
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Highly Cited
1999
Highly Cited
1999
Expression analysis of six paralogous human hyaluronidase genes clustered on chromosomes 3p21 and 7q31.
A. Csoka
,
S. Scherer
,
R. Stern
Genomics
1999
Corpus ID: 19427270
Two new members of a family of putative hyaluronidase genes involved in glycosaminoglycan catabolism have been identified and…
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Highly Cited
1999
Highly Cited
1999
Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX.
B. Triggs-Raine
,
T. Salo
,
H. Zhang
,
B. Wicklow
,
M. Natowicz
Proceedings of the National Academy of Sciences…
1999
Corpus ID: 23625477
Hyaluronan (HA), a large glycosaminoglycan abundant in the extracellular matrix, is important in cell migration during embryonic…
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Highly Cited
1997
Highly Cited
1997
Purification, cloning, and expression of human plasma hyaluronidase.
G. Frost
,
A. Csóka
,
T. Wong
,
R. Stern
Biochemical and biophysical research…
1997
Corpus ID: 36832757
Hyaluronidase was purified from human plasma using Triton X-114 phase extractions and ion-exchange chromatography. Monoclonal…
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Review
1997
Review
1997
Why did the sperm cross the cumulus? To get to the oocyte. Functions of the sperm surface proteins PH-20 and fertilin in arriving at, and fusing with, the egg.
D. Myles
,
P. Primakoff
Biology of reproduction
1997
Corpus ID: 5841381
The sperm surface has an active role in the events of fertilization. The definition of the sperm surface in both its composition…
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Highly Cited
1994
Highly Cited
1994
A hyaluronidase activity of the sperm plasma membrane protein PH-20 enables sperm to penetrate the cumulus cell layer surrounding the egg
Y. Lin
,
K. Mahan
,
W. Lathrop
,
D. Myles
,
P. Primakoff
The Journal of cell biology
1994
Corpus ID: 2816540
A typical mammalian egg is surrounded by an outer layer of about 3,000 cumulus cells embedded in an extracellular matrix rich in…
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Highly Cited
1990
Highly Cited
1990
Evidence that proteolysis of the surface is an initial step in the mechanism of formation of sperm cell surface domains
B. M. Phelps
,
D. Koppel
,
P. Primakoff
,
D. Myles
The Journal of cell biology
1990
Corpus ID: 6716969
On terminally differentiated sperm cells, surface proteins are segregated into distinct surface domains that include the anterior…
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Highly Cited
1990
Highly Cited
1990
cDNA cloning reveals the molecular structure of a sperm surface protein, PH-20, involved in sperm-egg adhesion and the wide distribution of its gene among mammals
W. Lathrop
,
E. Carmichael
,
D. Myles
,
P. Primakoff
The Journal of cell biology
1990
Corpus ID: 357498
Sperm binding to the egg zona pellucida in mammals is a cell-cell adhesion process that is generally species specific. The guinea…
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Highly Cited
1985
Highly Cited
1985
A role for the migrating sperm surface antigen PH-20 in guinea pig sperm binding to the egg zona pellucida
P. Primakoff
,
H. Hyatt
,
D. Myles
The Journal of cell biology
1985
Corpus ID: 11311873
After the acrosome reaction, the PH-20 surface antigen of guinea pig sperm migrates from its original location on the posterior…
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