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SPAM1 wt Allele

Known as: HYA1, MGC26532, SPAG15 
Human SPAM1 wild-type allele is located in the vicinity of 7q31.3 and is approximately 46 kb in length. This allele, which encodes hyaluronidase PH… 
National Institutes of Health

Related topics

Related topics

7 relations
7q31.3Carbohydrate MetabolismCell AdhesionFertilization

Broader (1)

SPAM1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization
The angiotensin-converting enzyme (ACE) is a key regulator of blood pressure. It is known to cleave small peptides, such as… 
Highly Cited
2002
Highly Cited
2002
Regulation of Hyaluronidase Activity by Alternative mRNA Splicing*
Hyaluronidase is a hyaluronic acid-degrading endoglycosidase that is present in many toxins and the levels of which are elevated… 
Highly Cited
1996
Highly Cited
1996
Sperm surface protein PH-20 is bifunctional: one activity is a hyaluronidase and a second, distinct activity is required in secondary sperm-zona binding.
In previous studies, we have found that the sperm membrane protein PH-20 acts during two different stages of fertilization. On… 
Highly Cited
1994
Highly Cited
1994
A hyaluronidase activity of the sperm plasma membrane protein PH-20 enables sperm to penetrate the cumulus cell layer surrounding the egg
A typical mammalian egg is surrounded by an outer layer of about 3,000 cumulus cells embedded in an extracellular matrix rich in… 
Highly Cited
1990
Highly Cited
1990
cDNA cloning reveals the molecular structure of a sperm surface protein, PH-20, involved in sperm-egg adhesion and the wide distribution of its gene among mammals
Sperm binding to the egg zona pellucida in mammals is a cell-cell adhesion process that is generally species specific. The guinea… 
Highly Cited
1988
Highly Cited
1988
Restricted lateral diffusion of PH-20, a PI-anchored sperm membrane protein.
The rate of lateral diffusion of integral membrane proteins is constrained in cells, but the constraining factors for most… 
Highly Cited
1987
Highly Cited
1987
Lateral diffusion of the PH-20 protein on guinea pig sperm: evidence that barriers to diffusion maintain plasma membrane domains in mammalian sperm
PH-20 protein on the plasma membrane (PH-20PM) is restricted to the posterior head of acrosome-intact guinea pig sperm. During… 
Highly Cited
1987
Highly Cited
1987
Binding of both acrosome-intact and acrosome-reacted guinea pig sperm to the zona pellucida during in vitro fertilization.
Highly Cited
1986
Highly Cited
1986
Sperm exocytosis increases the amount of PH-20 antigen on the surface of guinea pig sperm
Evidence has been presented that the PH-20 protein functions in sperm adhesion to the egg zona pellucida (Primakoff, P., H. Hyatt… 
Highly Cited
1985
Highly Cited
1985
A role for the migrating sperm surface antigen PH-20 in guinea pig sperm binding to the egg zona pellucida
After the acrosome reaction, the PH-20 surface antigen of guinea pig sperm migrates from its original location on the posterior… 
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