SPAM1 wt Allele

Known as: HYA1, MGC26532, SPAG15 
Human SPAM1 wild-type allele is located in the vicinity of 7q31.3 and is approximately 46 kb in length. This allele, which encodes hyaluronidase PH… (More)
National Institutes of Health

Related topics

Related topics

7 relations
7q31.3Carbohydrate MetabolismCell AdhesionFertilization
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Broader (1)

SPAM1 gene

Papers overview

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Highly Cited
2005
Highly Cited
2005
Angiotensin-converting enzyme is a GPI-anchored protein releasing factor crucial for fertilization
The angiotensin-converting enzyme (ACE) is a key regulator of blood pressure. It is known to cleave small peptides, such as… (More)
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2003
2003
Mouse epididymal Spam1 (pH-20) is released in the luminal fluid with its lipid anchor.
Previously we demonstrated that the murine sperm adhesion molecule 1 (Spam1 or PH-20) is synthesized by the epididymal epithelium… (More)
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Highly Cited
2002
Highly Cited
2002
Mouse sperm lacking cell surface hyaluronidase PH-20 can pass through the layer of cumulus cells and fertilize the egg.
The function of glycosylphosphatidylinositol-anchored sperm hyaluronidase PH-20 in fertilization has long been believed to enable… (More)
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Highly Cited
1999
Highly Cited
1999
Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX.
Hyaluronan (HA), a large glycosaminoglycan abundant in the extracellular matrix, is important in cell migration during embryonic… (More)
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Highly Cited
1997
Highly Cited
1997
Purification, cloning, and expression of human plasma hyaluronidase.
Hyaluronidase was purified from human plasma using Triton X-114 phase extractions and ion-exchange chromatography. Monoclonal… (More)
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Review
1997
Review
1997
Why did the sperm cross the cumulus? To get to the oocyte. Functions of the sperm surface proteins PH-20 and fertilin in arriving at, and fusing with, the egg.
The sperm surface has an active role in the events of fertilization. The definition of the sperm surface in both its composition… (More)
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Highly Cited
1994
Highly Cited
1994
A hyaluronidase activity of the sperm plasma membrane protein PH-20 enables sperm to penetrate the cumulus cell layer surrounding the egg
A typical mammalian egg is surrounded by an outer layer of about 3,000 cumulus cells embedded in an extracellular matrix rich in… (More)
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1988
1988
Restricted lateral diffusion of PH-20, a PI-anchored sperm membrane protein.
The rate of lateral diffusion of integral membrane proteins is constrained in cells, but the constraining factors for most… (More)
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1987
1987
Lateral diffusion of the PH-20 protein on guinea pig sperm: evidence that barriers to diffusion maintain plasma membrane domains in mammalian sperm
PH-20 protein on the plasma membrane (PH-20PM) is restricted to the posterior head of acrosome-intact guinea pig sperm. During… (More)
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1985
1985
A role for the migrating sperm surface antigen PH-20 in guinea pig sperm binding to the egg zona pellucida
After the acrosome reaction, the PH-20 surface antigen of guinea pig sperm migrates from its original location on the posterior… (More)
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