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SPAM1 gene

Known as: PH20, Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) Gene, HYAL5 
This gene plays a role in the modulation of cell adhesion of spermatozoa.
National Institutes of Health

Related topics

Related topics

8 relations
Carbohydrate MetabolismCell AdhesionFertilizationHYAL1 gene

Broader (1)

Genes

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SPAM1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
PH20 is not expressed in murine CNS and oligodendrocyte precursor cells
Expression of Spam1/PH20 and its modulation of high/low molecular weight hyaluronan substrate have been proposed to play an… 
2014
2014
Characterization of pig sperm hyaluronidase and improvement of the digestibility of cumulus cell mass by recombinant pSPAM1 hyaluronidase in an in vitro fertilization assay.
Review
2014
Review
2014
Development of antifertility vaccine using sperm specific proteins
Sperm proteins are known to be associated with normal fertilization as auto- or iso-antibodies to these proteins may cause… 
2002
2002
Characterization of PH-20 in canine spermatozoa and testis.
2002
2002
Expression and activity of hyaluronidase in human periodontal ligament fibroblasts.
BACKGROUND Hyaluronan is a major component of the extracellular matrix of periodontal ligament (PDL) contributing to the… 
1999
1999
PH‐20 but not acrosin is involved in sperm penetration of the macaque zona pellucida
In this study, we investigated the functions of PH‐20 and acrosin during the interaction of macaque sperm with the zona pellucida… 
1998
1998
Rearrangement of the PH‐20 protein on the surface of macaque spermatozoa following exposure to anti‐PH‐20 antibodies or binding to zona pellucida
Capacitated cynomolgus macaque sperm have a surface hyaluronidase (PH‐20) that is evenly distributed over the entire head and can… 
1997
1997
Biochemical characterization of the PH‐20 protein on the plasma membrane and inner acrosomal membrane of cynomolgus macaque spermatozoa
Preparations of sperm membranes (plasma membranes and outer acrosomal membranes) and denuded sperm heads were isolated from… 
Review
1997
Review
1997
Selection of antigens for use in a virus-vectored immunocontraceptive vaccine: PH-20 as a case study.
The European wild rabbit (Oryctolagus cuniculus) has become the major agricultural and environmental pest species in Australia… 
Review
1994
Review
1994
Review: Sperm Proteins Being Studied for Use in a Contraceptive Vaccine
In this review article seven basic characteristics necessary in the development of a contraceptive vaccine from sperm protein… 
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