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SPAG5 gene

Known as: hMAP126, sperm associated antigen 5, MITOTIC SPINDLE-ASSOCIATED PROTEIN, 126-KD 
National Institutes of Health

Papers overview

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Highly Cited
2017
Highly Cited
2017
Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells
Human chromosomes are captured along microtubule walls (lateral attachment) and then tethered to microtubule-ends (end-on… 
Highly Cited
2016
Highly Cited
2016
miR-539 inhibits prostate cancer progression by directly targeting SPAG5
We conducted multiple microarray datasets analyses from clinical and xenograft tumor tissues to search for disease progression… 
Highly Cited
2013
Highly Cited
2013
Inhibition of mTORC1 by Astrin and Stress Granules Prevents Apoptosis in Cancer Cells
Highly Cited
2013
Highly Cited
2013
Comparative Phosphoproteomic Analysis of Checkpoint Recovery Identifies New Regulators of the DNA Damage Response
Cells arrested by damaged DNA need astrin to enable the cell cycle to resume. Uncovering the Damage Recovery Phosphoproteome DNA… 
Highly Cited
2011
Highly Cited
2011
The astrin–kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment
Kinastrin is identified as a major interacting partner for astrin in mitotic cells, and is required for astrin targeting to… 
Highly Cited
2010
Highly Cited
2010
Aurora B kinase controls the targeting of the Astrin–SKAP complex to bioriented kinetochores
Localization of the spindle and kinetochore proteins Astrin, SKAP, and LC8 is antagonized by Aurora B so that they target… 
Highly Cited
2010
Highly Cited
2010
CLASP1, astrin and Kif2b form a molecular switch that regulates kinetochore‐microtubule dynamics to promote mitotic progression and fidelity
Accurate chromosome segregation during mitosis requires precise coordination of various processes, such as chromosome alignment… 
Highly Cited
2007
Highly Cited
2007
Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity
Faithful chromosome segregation in mitosis requires the formation of a bipolar mitotic spindle with stably attached chromosomes… 
Highly Cited
2002
Highly Cited
2002
The mitotic-spindle-associated protein astrin is essential for progression through mitosis
Astrin is a mitotic-spindle-associated protein expressed in most human cell lines and tissues. However, its functions in spindle… 
Highly Cited
2001
Highly Cited
2001
Analysis of mitotic microtubule-associated proteins using mass spectrometry identifies astrin, a spindle-associated protein
We purified microtubules from a mammalian mitotic extract and obtained an amino acid sequence from each microtubule-associated… 
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