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Mice lacking histidine decarboxylase exhibit abnormal mast cells
Histidine decarboxylase (HDC) synthesizes histamine from histidine in mammals. To evaluate the role of histamine, we generated HDC‐deficient mice using a gene targeting method. The mice showed a… Expand
Apparent digestible and metabolizable energy content of glycerol in feed of growing pigs
Abstract Two experiments were conducted each with the same 12 pigs in the growing and finishing phase to determine the apparent digestible (DE) and metabolizable energy (ME) content of crude glycerol… Expand
Suppression of melanoma cell proliferation by histidine decarboxylase specific antisense oligonucleotides.
- H. Hegyesi, B. Somlai, +8 authors Z. Darvas
- Biology, Medicine
- The Journal of investigative dermatology
- 1 July 2001
Histidine decarboxylase (HDC) is expressed by the cells of melanoma, in which the histamine content tends to be relatively high. This study shows that elevated expression of HDC was found by western… Expand
Contribution of phopholipase D and a brefeldin A‐sensitive ARF to chemoattractant‐induced superoxide production and secretion of human neutrophils
- K. Káldi, J. Szeberényi, +4 authors E. Ligeti
- Biology, Medicine
- Journal of leukocyte biology
- 1 April 2002
We show that blockers of phospholipase D (PLD) reduce fMLP‐triggered exocytosis of secretory vesicles effectively. In accordance with this, the PLD product phosphatidic acid (PA) was able to induce… Expand
Effect of glucosphingolipid synthesis inhibitor (PPMP and PDMP) treatment on Tetrahymena pyriformis: data on the evolution of the signaling system
1‐Phenyl‐2‐decanoylamino‐3‐morpholino‐1‐propanol (PDMP) and 1‐phenyl‐2‐palmitoylamino‐3‐morpholino‐1‐propanol (PPMP) are structural analogues of ceramide; inhibiting UDP‐glucose : ceramide… Expand
Effects of phosphoprotein phosphatase inhibitors (phenylarsine oxide and cantharidin) on Tetrahymena
The effects of phenylarsine oxide (PAO) (phosphotyrosine phosphatase inhibitor) and cantharidin (serine/threonine phosphatase [PP2A] inhibitor) treatments were analysed on the synthesis of… Expand
Effect of insulin on the incorporation of3H-inositol into the inositol phospholipids (PI, PIP, PIP2) and Glycosyl-phoshatidylinositols (GPIs) of Tetrahymena pyriformis
The unicellular tetrahymena contains inositol phospholipids (PI, PIP, PIP2) and GPIs. Treatment with 10−5M insulin decreases the total3H-inositol incorporation and incorporation into PI. 24 h after… Expand
Immunologically demonstrable hormones and hormone‐like molecules in rat white blood cells and mast cells
The presence or absence of four biologically active hormone or hormone‐like molecules was studied in rat immune cells using specific antibodies with flow cytometry and confocal microscopy. Epidermal… Expand
Bone marrow-derived mast cell differentiation is strongly reduced in histidine decarboxylase knockout, histamine-free mice.
Mast cells are differentiated in vitro from bone marrow precursors. In this study the development of bone marrow-derived mast cells was examined from histidine decarboxylase deficient (HDC-/-) and… Expand
Effect of the inhibition of triiodothyronine (T3) production by thiamazole on the T3 and serotonin content of immune cells.
Triiodothyronine (T3) and serotonin are present in the cells of immune system (blood, peritoneal and thymic lymphocytes, monocytes and granulocytes of the blood and peritoneal fluid, mast cells). In… Expand