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SORCS2 gene

Known as: sortilin related VPS10 domain containing receptor 2, SORCS RECEPTOR 2, SORCS2 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Genes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
SorCS2 Controls Functional Expression of Amino Acid Transporter EAAT3 and Protects Neurons from Oxidative Stress and Epilepsy-Induced Pathology
2018
2018
Structural insights into SorCS2–Nerve Growth Factor complex formation
Signaling of SorCS receptors by proneurotrophin ligands regulates neuronal plasticity, induces apoptosis and is associated with… 
2017
2017
SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's disease.
Motor dysfunction is a prominent and disabling feature of Huntington's disease (HD), but the molecular mechanisms that dictate… 
Highly Cited
2016
Highly Cited
2016
SorCS2 is required for BDNF-dependent plasticity in the hippocampus
SorCS2 is a member of the Vps10p-domain receptor gene family receptors with critical roles in the control of neuronal viability… 
Highly Cited
2015
Highly Cited
2015
New suggestive genetic loci and biological pathways for attention function in adult attention‐deficit/hyperactivity disorder
Attention deficit is one of the core symptoms of the attention‐deficit/hyperactivity disorder (ADHD). However, the specific… 
2014
2014
p75NTR, but Not proNGF, Is Upregulated Following Status Epilepticus in Mice
ProNGF and p75NTR are upregulated and induce cell death following status epilepticus (SE) in rats. However, less is known about… 
Highly Cited
2012
Highly Cited
2012
Discovery and Replication of Gene Influences on Brain Structure Using LASSO Regression
We implemented least absolute shrinkage and selection operator (LASSO) regression to evaluate gene effects in genome-wide… 
Review
2012
Review
2012
The role of intracellular trafficking and the VPS10d receptors in Alzheimer's disease.
  • C. Reitz
  • Future Neurology
  • 2012
  • Corpus ID: 26183743
In Alzheimer's disease, the key pathological culprit is the amyloid-β protein, which is generated through β- and γ-secretase… 
Highly Cited
2006
Highly Cited
2006
Tumour necrosis factor alpha-converting enzyme mediates ectodomain shedding of Vps10p-domain receptor family members.
Several transmembrane molecules are cleaved at juxtamembrane extracellular sites leading to shedding of ectodomains. We analysed… 
Highly Cited
2001
Highly Cited
2001
Identification of SorCS2, a novel member of the VPS10 domain containing receptor family, prominently expressed in the developing mouse brain
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