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SNCG gene

Known as: PERSYN, Synuclein, Gamma (Breast Cancer-Specific Protein 1) Gene, BREAST CANCER-SPECIFIC GENE 1 
This gene plays a role in central nervous development and has implicated in the in the pathogenesis of neurodegenerative diseases.
National Institutes of Health

Related topics

Related topics

6 relations
Breast CarcinomaCytoskeletal ModelingDegenerative Diseases, Central Nervous SystemGamma synuclein

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SNCG wt Allele

Papers overview

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2006
2006
The role of CpG islands hypomethylation and abnormal expression of neuronal protein synuclein-gamma (SNCG) in ovarian cancer.
BACKGROUND The synucleins are a family of small cytoplasmic proteins that are expressed predominantly in neurons. Recently, their… 
Highly Cited
2005
Highly Cited
2005
Synuclein Gamma Inhibits the Mitotic Checkpoint Function and Promotes Chromosomal Instability of Breast Cancer Cells
SummaryAberrant expressions of the neuronal protein synuclein gamma (SNCG) in malignant mammary epithelial cells are strongly… 
Highly Cited
2004
Highly Cited
2004
Bone morphogenetic protein 2 (BMP-2) induces in vitro invasion and in vivo hormone independent growth of breast carcinoma cells.
Breast cancer cell lines migrated towards a BMP-2 source depending on BMP-2 concentration. After a short exposure to BMP-2, the… 
Highly Cited
2003
Highly Cited
2003
Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1
The abnormal expression of breast cancer-specific gene 1 (BCSG1) in malignant mammary epithelial cells is highly associated with… 
Highly Cited
2003
Highly Cited
2003
Hypomethylation of the Synuclein γ Gene CpG Island Promotes Its Aberrant Expression in Breast Carcinoma and Ovarian Carcinoma
Recent studies indicate that synuclein γ (SNCG) gene, located in chromosome 10, participates in the pathogenesis of the breast… 
Highly Cited
2002
Highly Cited
2002
Blockade of AP1 Transactivation Abrogates the Abnormal Expression of Breast Cancer-specific Gene 1 in Breast Cancer Cells*
Breast cancer-specific gene 1 (BCSG1) is not expressed in normal breast tissue but is highly expressed in the vast majority of… 
Highly Cited
2001
Highly Cited
2001
Molecular mechanisms for aberrant expression of the human breast cancer specific gene 1 in breast cancer cells: control of transcription by DNA methylation and intronic sequences
Breast cancer specific gene 1 (BCSG1), also referred as synuclein γ, is the third member of a neuronal protein family synuclein… 
Highly Cited
1999
Highly Cited
1999
Stimulation of breast cancer invasion and metastasis by synuclein gamma.
We recently identified and cloned novel breast cancer-specific gene BCSG1 by direct differential cDNA sequencing. BCSG1 has a… 
Highly Cited
1998
Highly Cited
1998
Organization, expression and polymorphism of the human persyn gene.
Persyn is a recently identified member of the synuclein family with a distinct pattern of expression during pre- and postnatal… 
Review
1998
Review
1998
Identification, localization and characterization of the human γ-synuclein gene
We have identified and characterized a new member of the human synuclein gene family, γ-synuclein (SNCG). This gene is composed… 
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