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SMAD5 gene

Known as: JV5-1, MADH5, SMA- AND MAD-RELATED PROTEIN 5 
This gene is involved in signal transduction-mediated transcriptional regulation.
National Institutes of Health

Related topics

Related topics

9 relations
Homo sapiensPattern FormationReceptor SignalingSMAD1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
The BMP signaling pathway leads to enhanced proliferation in serous ovarian cancer—A potential therapeutic target
Members of the transforming growth factor‐β (TGF‐β) superfamily transduce signals via SMAD proteins. SMAD2 and SMAD3 mediate TGF… 
2014
2014
BMP‐2 Induction of Dlx3 Expression Is Mediated by p38/Smad5 Signaling Pathway in Osteoblastic MC3T3‐E1 Cells
Dlx3 is essential for osteoblast differentiation and bone formation, and its expression is regulated by bone morphogenetic… 
2014
2014
Temporal regulation of mRNAs for select bone morphogenetic proteins (BMP), BMP receptors and their associated SMAD proteins during bovine early embryonic development: effects of exogenous BMP2 on…
BackgroundWe previously demonstrated embryotrophic actions of maternal (oocyte-derived) follistatin during bovine early… 
Highly Cited
2010
Highly Cited
2010
Canonical BMP signaling is dispensable for hematopoietic stem cell function in both adult and fetal liver hematopoiesis, but essential to preserve colon architecture.
Numerous publications have described the importance of bone morphogenetic protein (BMP) signaling in the specification of… 
Highly Cited
2007
Highly Cited
2007
Smad1 and Smad5 differentially regulate embryonic hematopoiesis.
The bone morphogenetic protein (BMP) signaling pathway regulates multiple steps of hematopoiesis, mediated through receptor… 
2006
2006
Smad5 is dispensable for adult murine hematopoiesis.
Smad5 is known to transduce intracellular signals from bone morphogenetic proteins (BMPs), which belong to the transforming… 
Highly Cited
2003
Highly Cited
2003
Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5.
Whereas bone morphogenetic protein (BMP)-signaling events induce maturational characteristics in vitro, recent evidence suggests… 
2003
2003
Up-regulated Smad5 Mediates Apoptosis of Gastric Epithelial Cells Induced by Helicobacter pylori Infection*
The gastric pathogen Helicobacter pylori activates epithelial cell signaling pathways, and its infection induces changes in the… 
2002
2002
Inhibition of Smad5 in human hematopoietic progenitors blocks erythroid differentiation induced by BMP4.
Patients with secondary myelodysplasias and acute myeloid leukemias (MDS/AML) frequently exhibit interstitial deletions of the… 
2002
2002
Internal ribosome entry site-mediated translation of Smad5 in vivo: requirement for a nuclear event
Smad5 is thought to relay signals of the bone morphogenetic protein pathway. The 5' untranslated region (5'UTR) of human Smad5… 
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