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SM 19712

Known as: SM-19712 
National Institutes of Health

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2 relations

Broader (2)

SulfonamidesSulfonylurea Compounds

Papers overview

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2013
2013
Endothelin-converting-enzyme 1 inhibition and CGRP receptor recycling in human coronary and middle meningeal arteries
Although best known for its role in the conversion of big endothelin to endothelin-1, endothelin-converting enzyme 1 (ECE-1) also… 
2011
2011
Endothelin‐converting enzyme‐1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones
Non‐Technical Summary  The movement of receptors to and from the surface of nerve cells determines whether nerves can detect and… 
2011
2011
Effects of exogenous big endothelin-1 on postischemic cardiac dysfunction and norepinephrine overflow in rat hearts
Endothelin-1 (ET-1) is involved in norepinephrine (NE) overflow and cardiac dysfunction after myocardial ischemia/reperfusion via… 
2011
2011
Contribution of Nitric Oxide in Big Endothelin-1–induced Cardioprotective Effects on Ischemia/Reperfusion Injury in Rat Hearts
We have recently shown that an appropriate amount of exogenous big endothelin-1 (ET-1) has beneficial effects on ischemia… 
2009
2009
Endothelin‐converting enzyme 1 promotes re‐sensitization of neurokinin 1 receptor‐dependent neurogenic inflammation
Background and purpose:  The metalloendopeptidase endothelin‐converting enzyme 1 (ECE‐1) is prominently expressed in the… 
2009
2009
Effects of the endothelin‐converting enzyme inhibitor SM‐19712 in a mouse model of dextran sodium sulfate‐induced colitis
Background: Ingestion by mice of dextran sodium sulfate (DSS) induces colonic vasoconstriction and inflammation, with some of the… 
Highly Cited
2009
Highly Cited
2009
Fibrinogen-induced endothelin-1 production from endothelial cells.
We previously demonstrated that fibrinogen (Fg) binding to the vascular endothelial intercellular adhesion molecule-1 (ICAM-1… 
2004
2004
Endothelin-converting enzyme inhibitors and their potential for cardiovascular and renal therapeutics
Inhibition of endothelin-converting enzyme (ECE) will reduce the levels of endothelin-1 (ET-1). A pathological effect for ECE/ET… 
2000
2000
Pharmacological characterization of a novel sulfonylureid-pyrazole derivative, SM-19712, a potent nonpeptidic inhibitor of endothelin converting enzyme.
We describe the pharmacological characteristics of SM-19712 (4-chloro-N-[[(4-cyano-3-methyl-1-phenyl-1H-pyrazol-5-yl)amino… 
2000
2000
Protective effect of SM-19712, a novel and potent endothelin converting enzyme inhibitor, on ischemic acute renal failure in rats.
Effects of SM-19712 (4-chloro-N-[[(4-cyano-3-methyl- 1-1-phenyl- 1H-pyrazol-5-yl)amino]carbonyl] benzenesulfonamide, monosodium… 
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