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SM 164

Known as: SM-164, SM164 
National Institutes of Health

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2 relations

Broader (2)

Bridged Bicyclo Compounds, HeterocyclicTriazoles

Papers overview

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2013
2013
Therapy of Smac mimetic SM-164 in combination with gemcitabine for pancreatic cancer.
2012
2012
LRIG1 modulates cancer cell sensitivity to Smac mimetics by regulating TNFα expression and receptor tyrosine kinase signaling.
Smac mimetics block inhibitor of apoptosis proteins to trigger TNFα-dependent apoptosis in cancer cells. However, only a small… 
2012
2012
Therapeutics , Targets , and Chemical Biology LRIG 1 Modulates Cancer Cell Sensitivity to Smac Mimetics by Regulating TNF a Expression and Receptor Tyrosine Kinase Signaling
Smac mimetics block inhibitor of apoptosis proteins to trigger TNFa-dependent apoptosis in cancer cells. However, only a small… 
2011
2011
Abstract 3254: Novel bivalent Smac mimetics as a new class of anticancer agents
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Second mitochondria-derived activator of caspase (Smac… 
2010
2010
Efficacy of MDM2 inhibitor MI-219 against lung cancer cells alone or in combination with MDM2 knockdown, a XIAP inhibitor or etoposide.
The p53 tumor suppressor is negatively regulated by murine double minute 2 (MDM2), which binds to p53 and promotes p53… 
2010
2010
Abstract 3489: Profound cytotoxicity of the histone deacetylase inhibitor SAHA (Suberoylanilide Hydroxamic Acid) and TRAIL (Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand) combination in…
Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC Background: The majority of solid malignancies… 
2007
2007
Synergistic anti-tumor effect with combination of a novel small molecule Smac mimetic compound (SM-164) and agonist TRAIL-R monoclonal Abs (Mapatumumab & Lexatumumab).
AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA 4871 Background: Agonism of the TRAIL receptor (TRAIL-R) pathway by… 
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