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SLX4 wt Allele

Known as: KIAA1784, FANCP, BTB (POZ) Domain Containing 12 Gene 
Human SLX4 wild-type allele is located in the vicinity of 16p13.3 and is approximately 30 kb in length. This allele, which encodes structure-specific… Expand
National Institutes of Health

Related topics

Related topics

3 relations
16p13.3DNA RepairEnzyme Induction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Alterations of DNA repair genes in the NCI-60 cell lines and their predictive value for anticancer drug activity.
Loss of function of DNA repair (DNAR) genes is associated with genomic instability and cancer predisposition; it also makes… Expand
2015
2015
Whole-exome sequencing of a rare case of familial childhood acute lymphoblastic leukemia reveals putative predisposing mutations in Fanconi anemia genes
BackgroundAcute lymphoblastic leukemia (ALL) is the most common pediatric cancer. While the multi-step model of pediatric… Expand
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2015
2015
Chapter 3 Whole exome sequencing reveals uncommon mutations in the recently identified Fanconi anemia gene SLX 4 / FANCP
 
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Highly Cited
2013
Highly Cited
2013
Regulation of multiple DNA repair pathways by the Fanconi anemia protein SLX4.
SLX4, the newly identified Fanconi anemia protein, FANCP, is implicated in repairing DNA damage induced by DNA interstrand cross… Expand
2012
2012
The nuclease hSNM 1 B / Apollo is linked to the Fanconi anemia pathway via its interaction with FANCP / SLX 4
The recessive genetic disorder Fanconi anemia (FA) is clinically characterized by congenital defects, bone marrow failure and an… Expand
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Highly Cited
2011
Highly Cited
2011
Mutations of the SLX4 gene in Fanconi anemia
Fanconi anemia is a rare recessive disorder characterized by genome instability, congenital malformations, progressive bone… Expand
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Highly Cited
2011
Highly Cited
2011
Mammalian BTBD12 (SLX4) Protects against Genomic Instability during Mammalian Spermatogenesis
The mammalian ortholog of yeast Slx4, BTBD12, is an ATM substrate that functions as a scaffold for various DNA repair activities… Expand
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2011
2011
Cancel all Hollidays for SLX4 mutations: identification of a new Fanconi anemia subtype, FANCP
  • M. Kang
  • Clinical genetics
  • 2011
    • Corpus ID: 38007184
SLX4, a coordinator of structure‐specific endo‐nucleases, is mutated in a new Fanconi anemia subtype 
2011
2011
HotSpots Cancel all Hollidays for SLX 4 mutations : identification of a new Fanconi anemia subtype , FANCP
For the clinician, the two major challenges in correctly diagnosing Fanconi anemia (FA; OMIM# 227650) are its clinical… Expand
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