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SLCO1A2 gene

Known as: OATP-A, solute carrier organic anion transporter family member 1A2, SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY, MEMBER 1A2 
National Institutes of Health

Related topics

Related topics

1 relation
Organic Anion Transport Polypeptides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Intestinal Drug Interactions Mediated by OATPs: A Systematic Review of Preclinical and Clinical Findings.
Highly Cited
2014
Highly Cited
2014
Differential cellular expression of organic anion transporting peptides OATP1A2 and OATP2B1 in the human retina and brain: implications for carrier-mediated transport of neuropeptides and…
Organic anion transporting polypeptides (OATPs) are polyspecific organic anion transporters, which are expressed in the blood… 
Highly Cited
2012
Highly Cited
2012
Pharmaceutical excipients influence the function of human uptake transporting proteins.
Although pharmaceutical excipients are supposed to be pharmacologically inactive, solubilizing agents like Cremophor EL have been… 
Highly Cited
2011
Highly Cited
2011
Pharmacokinetic Impact of SLCO1A2 Polymorphisms on Imatinib Disposition in Patients With Chronic Myeloid Leukemia
The purpose of this study was to explore the role of the organic anion‐transporting polypeptide (OATP) 1A2, which is encoded by… 
Highly Cited
2011
Highly Cited
2011
Environmental and Genetic Factors Affecting Transport of Imatinib by OATP1A2
The bioavailability of orally administered imatinib is >90%, although the drug is monocationic under the acidic conditions in the… 
Highly Cited
2010
Highly Cited
2010
HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms
Objective OATP1B1 and OATP1B3 are major hepatic drug transporters whilst OATP1A2 is mainly located in the brain but is also… 
Highly Cited
2009
Highly Cited
2009
Use of mRNA expression to detect the induction of drug metabolising enzymes in rat and human hepatocytes.
Highly Cited
2006
Highly Cited
2006
Interaction of Methotrexate with Organic-Anion Transporting Polypeptide 1A2 and Its Genetic Variants
Methotrexate (MTX) is used in patients with malignant and autoimmune diseases. This drug is primarily excreted unchanged in the… 
Highly Cited
2006
Highly Cited
2006
Effect of SLCO1B1 genetic polymorphism on the pharmacokinetics of nateglinide.
AIMS Nateglinide is a meglitinide analogue with antidiabetic action. A recent study showed that SLCO1B1 (which codes the OATP1B1… 
Highly Cited
2005
Highly Cited
2005
Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1).
The H1-receptor antagonist fexofenadine is a P-glycoprotein substrate [1]. However, the effects of genetic polymorphisms of the… 
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