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SL651498

Known as: SL65.1498 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
GABAA receptor α2 subtype activation suppresses retinal spreading depression
2012
2012
Selective overexpression of Comt in prefrontal cortex rescues schizophrenia-like phenotypes in a mouse model of 22q11 deletion syndrome
The 22q11.2 microdeletion is one of the highest genetic risk factors for schizophrenia. It is not well understood which… 
Highly Cited
2009
Highly Cited
2009
The pharmacokinetic and pharmacodynamic effects of SL65.1498, a GABA-A 2,3 selective agonist, in comparison with lorazepam in healthy volunteers
Abstract Benzodiazepines are effective short-term treatments for anxiety disorders, but their use is limited by undesirable side… 
2006
2006
Comparative Cue Generalization Profiles of L-838, 417, SL651498, Zolpidem, CL218,872, Ocinaplon, Bretazenil, Zopiclone, and Various Benzodiazepines in Chlordiazepoxide and Zolpidem Drug…
The zolpidem discriminative cue is mediated by GABAA-α1 receptors, whereas the chlordiazepoxide cue may be mediated via non-α1… 
2006
2006
Do Subtype-Selective γ-Aminobutyric AcidA Receptor Modulators Have a Reduced Propensity to Induce Physical Dependence in Mice?
Recent evidence suggests that GABAA receptors containing an α1 subunit mediate the sedative effect of diazepam, whereas receptors… 
2005
2005
Contribution of GABAA Receptor Subtypes to the Anxiolytic-Like, Motor, and Discriminative Stimulus Effects of Benzodiazepines: Studies with the Functionally Selective Ligand SL651498 [6-Fluoro-9…
Benzodiazepines (BZs) are prescribed for a variety of disorders, including those involving anxiety and sleep, but have unwanted… 
Review
2003
Review
2003
Anxioselective compounds acting at the GABA(A) receptor benzodiazepine binding site.
  • J. Atack
  • Current Drug Targets - CNS & Neurological…
  • 2003
  • Corpus ID: 6478716
With the exception of obsessive compulsive disorder, benzodiazepines (BZs) remain a major first line treatment for anxiety… 
Highly Cited
2001
Highly Cited
2001
SL651498: An Anxioselective Compound with Functional Selectivity for α2- and α3-Containing γ-Aminobutyric AcidA (GABAA) Receptors
SL651498 [6-fluoro-9-methyl-2-phenyl-4-(pyrrolidin-1-yl-carbonyl)-2,9-dihydro-1 H -pyrido[3,4- b ]indol-1-one] is a novel… 
2001
2001
SL651498: an anxioselective compound with functional selectivity for alpha2- and alpha3-containing gamma-aminobutyric acid(A) (GABA(A)) receptors.
SL651498 [6-fluoro-9-methyl-2-phenyl-4-(pyrrolidin-1-yl-carbonyl)-2,9-dihydro-1H-pyrido[3,4-b]indol-1-one] is a novel… 
Review
2000
Review
2000
CNS Drug Reviews
This review focuses on the in vitro and in vivo neuropharmacology of YM872, a potential neuroprotective agent currently… 
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