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SK&F 89976-A

Known as: SKF 89976A 
 
National Institutes of Health

Papers overview

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2011
2011
Differential localization and function of GABA transporters, GAT‐1 and GAT‐3, in the rat globus pallidus
GABA transporter subtype 1 (GAT‐1) and GABA transporter subtype 3 (GAT‐3) are the main transporters that regulate inhibitory… Expand
2010
2010
In vitro activation of GAT1 transporters expressed in spinal cord gliosomes stimulates glutamate release that is abnormally elevated in the SOD1/G93A(+) mouse model of amyotrophic lateral sclerosis
J. Neurochem. (2010) 113, 489–501. 
Highly Cited
2009
Highly Cited
2009
Regulation of tonic GABA inhibitory function, presympathetic neuronal activity and sympathetic outflow from the paraventricular nucleus by astroglial GABA transporters
Neuronal activity in the hypothalamic paraventricular nucleus (PVN), as well as sympathetic outflow from the PVN, is basally… Expand
Highly Cited
2005
Highly Cited
2005
First Demonstration of a Functional Role for Central Nervous System Betaine/γ-Aminobutyric Acid Transporter (mGAT2) Based on Synergistic Anticonvulsant Action among Inhibitors of mGAT1 and mGAT2
In a recent study, EF1502 [N-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-hydroxy-4-(methylamino)-4,5,6,7-tetrahydrobenzo [d… Expand
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2004
2004
Brain-derived neurotrophic factor facilitates glutamate and inhibits GABA release from hippocampal synaptosomes through different mechanisms
Brain-derived neurotrophic factor (BDNF) has an acute excitatory effect on rat hippocampal synaptic transmission. To compare the… Expand
1999
1999
GABA induces norepinephrine exocytosis from hippocampal noradrenergic axon terminals by a dual mechanism involving different voltage‐sensitive calcium channels
GABA can evoke norepinephrine (NE) release by activating GABAA receptors or GABA transporters on noradrenergic terminals. The… Expand
Highly Cited
1994
Highly Cited
1994
Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1.
gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian brain. The synaptic action of GABA is… Expand
Highly Cited
1993
Highly Cited
1993
Depolarization by K+ and glutamate activates different neurotransmitter release mechanisms in gabaergic neurons: Vesicular versus non-vesicular release of GABA
Neurotransmitter release and changes in the concentration of intracellular free calcium ([Ca++]i) were studied in cultured… Expand
Highly Cited
1992
Highly Cited
1992
Pharmacological characterization of GABAB-mediated responses in the CA1 region of the rat hippocampal slice
It is generally accepted that the bicuculline-resistant responses to GABA are mediated through the activation of GABAB receptors… Expand
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1991
1991
Anticonvulsant Profiles of the Potent and Orally Active GABA Uptake Inhibitors SK&F 89976‐A and SK&F 100330‐A and Four Prototype Antiepileptic Drugs in Mice and Rats
Summary: The anticonvulsant profiles of two potent and orally active 7‐aminobutyric acid (GABA) uptake inhibitors, l‐(4,4… Expand
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