SK&F 104976

Lipid rafts are plasma membrane microdomains that are highly enriched with cholesterol and sphingolipids and in which various… (More)

Cholesterol metabolism is particularly active in malignant, proliferative cells, whereas cholesterol starvation has been shown to… (More)

Cholesterol is a major lipid component of the plasma membrane in animal cells. In addition to its structural requirement… (More)

Cholesterol is a major component of the plasma membrane in mammalian cells, where it acts as a modulator of bulk physical state… (More)

As an essential component of mammalian cell membranes, cells require cholesterol for proliferation, which is either obtained from… (More)

Cholesterol is essential for cell growth and division, but whether this is just a consequence of its use in membrane formation or… (More)

As a major component of mammalian cell plasma membranes, cholesterol is essential for cell growth. Accordingly, the restriction… (More)

To determine the role of cholesterol deprivation in cell proliferation and, eventually, in apoptosis, HL-60 promyelocytic cells… (More)

A 32-carboxylic acid derivative of lanosterol (SKF 104976) was found to be a potent inhibitor of lanosterol 14 alpha-demethylase… (More)