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SK&F 104976

Known as: SK&F-104976, SKF 104976 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Lanosterol
analogs & derivatives

Papers overview

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Highly Cited
2009
Highly Cited
2009
Inhibition of cholesterol biosynthesis disrupts lipid raft/caveolae and affects insulin receptor activation in 3T3-L1 preadipocytes.
Lipid rafts are plasma membrane microdomains that are highly enriched with cholesterol and sphingolipids and in which various… Expand
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2007
2007
Cholesterol starvation induces differentiation of human leukemia HL-60 cells.
Cholesterol metabolism is particularly active in malignant, proliferative cells, whereas cholesterol starvation has been shown to… Expand
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2005
2005
Sterol stringency of proliferation and cell cycle progression in human cells.
Cholesterol is a major component of the plasma membrane in mammalian cells, where it acts as a modulator of bulk physical state… Expand
Highly Cited
2004
Highly Cited
2004
Cholesterol is essential for mitosis progression and its deficiency induces polyploid cell formation.
As an essential component of mammalian cell membranes, cells require cholesterol for proliferation, which is either obtained from… Expand
1999
1999
Cholesterol starvation decreases p34(cdc2) kinase activity and arrests the cell cycle at G2.
As a major component of mammalian cell plasma membranes, cholesterol is essential for cell growth. Accordingly, the restriction… Expand
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1998
1998
Induction of apoptosis in p53-null HL-60 cells by inhibition of lanosterol 14-alpha demethylase.
To determine the role of cholesterol deprivation in cell proliferation and, eventually, in apoptosis, HL-60 promyelocytic cells… Expand
1991
1991
Effects of a novel lanosterol 14 alpha-demethylase inhibitor on the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in Hep G2 cells.
A 32-carboxylic acid derivative of lanosterol (SKF 104976) was found to be a potent inhibitor of lanosterol 14 alpha-demethylase… Expand
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