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SIRT5 gene

Known as: SIR2L5, SIRT5, SIR2, S. CEREVISIAE, HOMOLOG-LIKE 5 
National Institutes of Health

Related topics

Related topics

1 relation
SIRT3 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function
Significance Lysine succinylation is a recently discovered protein posttranslational modification and SIRT5 is an efficient… 
Highly Cited
2016
Highly Cited
2016
SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense
Excess in mitochondrial reactive oxygen species (ROS) is considered as a major cause of cellular oxidative stress. NADPH, the… 
Review
2016
Review
2016
The role of mitochondrial sirtuins in health and disease.
Highly Cited
2015
Highly Cited
2015
SIRT5 regulation of ammonia-induced autophagy and mitophagy
In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1, the first enzyme of the urea cycle… 
Highly Cited
2014
Highly Cited
2014
Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.
Highly Cited
2014
Highly Cited
2014
SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer
Lung cancer is one of the leading causes of cancer-related death in developed countries. Despite decades of intensive efforts to… 
Highly Cited
2013
Highly Cited
2013
SIRT5: A Safeguard Against Oxidative Stress-Induced Apoptosis in Cardiomyocytes
Background: SIRT5 is located in the mitochondria, and plays a crucial role in the regulation of metabolic process and cellular… 
Highly Cited
2012
Highly Cited
2012
A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol
Sirtuins are protein deacetylases regulating metabolism, stress responses, and aging processes, and they were suggested to… 
Highly Cited
2011
Highly Cited
2011
Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase
Biological functions of sirtuins may involve lysine desuccinylase and demalonylase activities. Silent information regulator 2… 
Highly Cited
2008
Highly Cited
2008
Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5.
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