SIRT5 gene

Known as: SIR2L5, SIRT5, SIR2, S. CEREVISIAE, HOMOLOG-LIKE 5 
 
National Institutes of Health

Related topics

Related topics

1 relation
SIRT3 gene

Papers overview

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2016
2016
Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function.
Cellular metabolites, such as acyl-CoA, can modify proteins, leading to protein posttranslational modifications (PTMs). One such… (More)
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2015
2015
SIRT5 regulation of ammonia-induced autophagy and mitophagy
In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1, the first enzyme of the urea cycle… (More)
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Highly Cited
2014
Highly Cited
2014
Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.
We report the identification and characterization of a five-carbon protein posttranslational modification (PTM) called lysine… (More)
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2014
2014
SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer
Lung cancer is one of the leading causes of cancer-related death in developed countries. Despite decades of intensive efforts to… (More)
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2013
2013
Metabolic Characterization of a Sirt5 deficient mouse model
Sirt5, localized in the mitochondria, is a member of sirtuin family of NAD⁺-dependent deacetylases. Sirt5 was shown to… (More)
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2013
2013
SIRT5: a safeguard against oxidative stress-induced apoptosis in cardiomyocytes.
BACKGROUND SIRT5 is located in the mitochondria, and plays a crucial role in the regulation of metabolic process and cellular… (More)
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2012
2012
The bicyclic intermediate structure provides insights into the desuccinylation mechanism of human sirtuin 5 (SIRT5).
Sirtuins are pivotal regulators in various cellular processes, including transcription, DNA repair, genome stability, and energy… (More)
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Highly Cited
2011
Highly Cited
2011
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.
Silent information regulator 2 (Sir2) proteins (sirtuins) are nicotinamide adenine dinucleotide-dependent deacetylases that… (More)
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2009
2009
Urea cycle regulation by mitochondrial sirtuin, SIRT5
Mammalian sirtuins have diverse roles in aging, metabolism and disease. Recently we reported a new function for SIRT5 in urea… (More)
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Highly Cited
2008
Highly Cited
2008
Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5.
The enzymes of the Sirtuin family of nicotinamide-adenine-dinucleotide-dependent protein deacetylases are emerging key players in… (More)
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