Skip to search formSkip to main contentSkip to account menu
You are currently offline. Some features of the site may not work correctly.

SIRT5 gene

Known as: SIR2L5, SIRT5, SIR2, S. CEREVISIAE, HOMOLOG-LIKE 5 
National Institutes of Health

Related topics

Related topics

1 relation
SIRT3 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function
Significance Lysine succinylation is a recently discovered protein posttranslational modification and SIRT5 is an efficient… 
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Highly Cited
2016
Highly Cited
2016
SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense
Excess in mitochondrial reactive oxygen species (ROS) is considered as a major cause of cellular oxidative stress. NADPH, the… 
Highly Cited
2015
Highly Cited
2015
SIRT5 regulation of ammonia-induced autophagy and mitophagy
In liver the mitochondrial sirtuin, SIRT5, controls ammonia detoxification by regulating CPS1, the first enzyme of the urea cycle… 
Highly Cited
2014
Highly Cited
2014
Lysine glutarylation is a protein posttranslational modification regulated by SIRT5.
We report the identification and characterization of a five-carbon protein posttranslational modification (PTM) called lysine… 
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Highly Cited
2014
Highly Cited
2014
SIRT5 facilitates cancer cell growth and drug resistance in non-small cell lung cancer
Lung cancer is one of the leading causes of cancer-related death in developed countries. Despite decades of intensive efforts to… 
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Highly Cited
2012
Highly Cited
2012
A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol
Sirtuins are protein deacetylases regulating metabolism, stress responses, and aging processes, and they were suggested to… 
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 5
Highly Cited
2011
Highly Cited
2011
Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase
Biological functions of sirtuins may involve lysine desuccinylase and demalonylase activities. Silent information regulator 2… 
Highly Cited
2010
Highly Cited
2010
Overexpression of SIRT5 confirms its involvement in deacetylation and activation of carbamoyl phosphate synthetase 1.
SIR2 protein, an NAD-dependent deacetylase, is localized to nucleus and is involved in life span extension by calorie restriction… 
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Highly Cited
2008
Highly Cited
2008
Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5.
The enzymes of the Sirtuin family of nicotinamide-adenine-dinucleotide-dependent protein deacetylases are emerging key players in… 
  • figure 1
  • figure 2
  • figure 4
  • figure 5
Highly Cited
2008
Highly Cited
2008
Opposing Effects of Sirtuins on Neuronal Survival: SIRT1-Mediated Neuroprotection Is Independent of Its Deacetylase Activity
Background Growing evidence suggests that sirtuins, a family of seven distinct NAD-dependent enzymes, are involved in the… 
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE