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SIN 1C

Known as: SIN-1C 
National Institutes of Health

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2 relations

Broader (2)

AcetonitrilesMorpholines

Papers overview

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Highly Cited
1999
Highly Cited
1999
The peroxynitrite generator, SIN-1, becomes a nitric oxide donor in the presence of electron acceptors.
SIN-1 has been used, in vitro, to simultaneously generate nitric oxide (*NO) and superoxide (O*-2). However, the pharmacological… 
1997
1997
Efficiency of aerosolized nitric oxide donor drugs to achieve sustained pulmonary vasodilation.
Inhalation of nitric oxide (NO) causes selective pulmonary vasodilation, but demands continuous supply of the gaseous agent. We… 
Highly Cited
1996
Highly Cited
1996
Decreased intraocular pressure induced by nitric oxide donors is correlated to nitrite production in the rabbit eye.
PURPOSE To evaluate the effect of intraocular administration of nitric oxide (NO) donors in the rabbit eye on intraocular… 
Highly Cited
1995
Highly Cited
1995
Inhibitory effect of nitric oxide on the replication of a murine retrovirus in vitro and in vivo
Nitric oxide (NO) exerts microbicidal effects on a broad spectrum of pathogens, including viruses, but its antiretrovirus… 
Highly Cited
1995
Highly Cited
1995
Nitric oxide regulates the calcium current in isolated human atrial myocytes.
Cardiac Ca2+ current (ICa) was shown to be regulated by cGMP in a number of different species. Recently, we found that the NO… 
Highly Cited
1994
Highly Cited
1994
NO donor SIN-1 protects against reoxygenation-induced cardiomyocyte injury by a dual action.
It was investigated whether morpholinosydnonimine (SIN-1), which spontaneously decomposes into NO and 3… 
Highly Cited
1993
Highly Cited
1993
Nitric oxide regulates cardiac Ca2+ current. Involvement of cGMP-inhibited and cGMP-stimulated phosphodiesterases through guanylyl cyclase activation.
Highly Cited
1989
Highly Cited
1989
On the Mechanism of NO Release from Sydnonimines
SUMMARY The vasodilator and antiaggregatory properties of sydnonimines like SIN-1 are thought to be due to their marked… 
Highly Cited
1989
Highly Cited
1989
Oxygen and Oxidation Promote the Release of Nitric Oxide from Sydnonimines
SUMMARY The antianginal effect of sydnonimines is believed to be due to the release of nitric oxide (NO) from inactive prodrugs… 
1985
1985
Relationship between pharmacokinetics and pharmacodynamics of molsidomine and its metabolites in humans.
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