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Myoglobin: A scavenger of bioactive NO.
The present study explored the role of myoglobin (Mb) in cardiac NO homeostasis and its functional relevance by employing isolated hearts of wild-type (WT) and myoglobin knockout mice. (1)H NMRExpand
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Inhibition of adenosine kinase increases endogenous adenosine and depresses neuronal activity in hippocampal slices
Endogenous adenosine in the extracellular space inhibits neuronal activity. The roles of adenosine kinase, S-adenosylhomocysteine-hydrolase and adenosine deaminase activities in the regulation of theExpand
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Hypoxia-induced inhibition of adenosine kinase potentiates cardiac adenosine release.
To elucidate the physiological role of the AMP-adenosine metabolic cycle and to investigate the relation between AMP and adenosine formation, the O2 supply of isolated guinea pig hearts was variedExpand
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Coronary hemodynamics in endothelial NO synthase knockout mice.
For the specific analysis of endothelial NO synthase (eNOS) function in the coronary vasculature, we generated a mouse homozygous for a defective eNOS gene (eNOS-/-). Western blot as well asExpand
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Targeted Disruption of cd73/Ecto-5′-Nucleotidase Alters Thromboregulation and Augments Vascular Inflammatory Response
To investigate the role of adenosine formed extracellularly in vascular homeostasis, mice with a targeted deletion of the cd73/ecto-5′-nucleotidase were generated. Southern blot, RT-PCR, and WesternExpand
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In vivo study of microcirculation in canine myocardium using the IVIM method †
The intravoxel incoherent motion (IVIM) method was implemented in closed‐chest dogs to obtain measurements on microcirculation in the left ventricular wall in vivo. Specifically, it enabled us toExpand
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Inotropic response to β‐adrenergic receptor stimulation and anti‐adrenergic effect of ACh in endothelial NO synthase‐deficient mouse hearts
1 The functional consequences of a lack of endothelial nitric oxide synthase (eNOS) on left ventricular force development and the anti‐adrenergic effect of acetylcholine (ACh) were investigated inExpand
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Disruption of myoglobin in mice induces multiple compensatory mechanisms.
Myoglobin may serve a variety of functions in muscular oxygen supply, such as O(2) storage, facilitated O(2) diffusion, and myoglobin-mediated oxidative phosphorylation. We studied the functionalExpand
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Functional role of TASK-1 in the heart: studies in TASK-1-deficient mice show prolonged cardiac repolarization and reduced heart rate variability
TASK-1, a member of the recently identified K2P channel family, is mainly expressed in the heart and the nervous system. TASK-1 is regulated by several physiological and pathological conditions andExpand
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Blocking Na(+)-H+ exchange by cariporide reduces Na(+)-overload in ischemia and is cardioprotective.
In myocardial ischemia, rapid inactivation of Na(+)-K(+)-ATPase and continuing influx of sodium induce Na(+)-overload which is the basis of Ca(2+)-overload and irreversible tissue injury followingExpand
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