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SIB 1893

Known as: SIB-1893, SIB1893 
National Institutes of Health

Related topics

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1 relation

Broader (1)

Pyridines

Papers overview

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Highly Cited
2004
Highly Cited
2004
Endogenous Activation of mGlu5 Metabotropic Glutamate Receptors Contributes to the Development of Nigro-Striatal Damage Induced by 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine in Mice
We combined the use of knock-out mice and subtype-selective antagonists [2-methyl-6-(phenylethynyl)pyridine (MPEP) and (E)-2… 
2004
2004
Noncompetitive Metabotropic Glutamate5 Receptor Antagonist (E)-2-Methyl-6-styryl-pyridine (SIB1893) Depresses Glutamate Release through Inhibition of Voltage-Dependent Ca2+ Entry in Rat…
The effect of (E)-2-methyl-6-styryl-pyridine (SIB1893), a selective metabotropic glutamate (subtype 5) receptor (mGlu5R… 
Review
2003
Review
2003
Glutamate metabotropic receptors as targets for drug therapy in epilepsy.
Highly Cited
2003
Highly Cited
2003
Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB‐1893 and MPEP
We have identified 2‐methyl‐6‐(2‐phenylethenyl)pyridine (SIB‐1893) and 2‐methyl‐6‐phenylethynyl pyridine hydrochloride (MPEP) as… 
2003
2003
Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice.
Review
2001
Review
2001
Metabotropic Glutamate Receptor Subtypes as Targets for Neuroprotective Drugs
Metabotropic glutamate (mGlu) receptors have been considered as potential targets for neuroprotective drugs, but the lack of… 
Highly Cited
2001
Highly Cited
2001
mGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2-phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-D-aspartate…
The effect of selective group I metabotropic glutamate receptor subtype 5 (mGluR5) antagonists 2-methyl-6-(phenylethynyl… 
Highly Cited
2000
Highly Cited
2000
Selective mGluR5 antagonists MPEP and SIB‐1893 decrease NMDA or glutamate‐mediated neuronal toxicity through actions that reflect NMDA receptor antagonism
The metabotropic glutamate receptors (mGluRs) are a family of G‐protein linked receptors that can be divided into three groups… 
Highly Cited
2000
Highly Cited
2000
Selective blockade of metabotropic glutamate receptor subtype 5 is neuroprotective
Highly Cited
1999
Highly Cited
1999
SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5.
Cell lines expressing the human metabotropic glutamate receptor subtype 5a (hmGluR5a) and hmGluR1b were used as targets in an… 
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