The New Generation of GABA Enhancers
Ganaxolone, retigabine and pregabalin may prove to have a more advantageous therapeutic profile than the presently licensed GABA enhancing drugs, and CGP 36742, a GABAb receptor antagonist, may be particularly useful in the management of primary generalised absence seizures.
Basic mechanisms of antiepileptic drugs and their pharmacokinetic/pharmacodynamic interactions: an update.
Preclinical Profile of Combinations of Some Second‐generation Antiepileptic Drugs: An Isobolographic Analysis
This study sought to determine the interactions among some newer AEDs in the maximal electroshock‐induced seizures (MES) and chimney test (motor performance) in mice, by using the isobolographic analysis.
Interactions of Lamotrigine with Topiramate and First‐generation Antiepileptic Drugs in the Maximal Electroshock Test in Mice: An Isobolographic Analysis
This study investigated the types of interactions between lamotrigine (LTG) and first‐generation antiepileptic drugs (AEDs) or topiramate (TPM) with isobolographic analysis.
Time–course and dose–response relationships of imperatorin in the mouse maximal electroshock seizure threshold model
Imperatorin enhances the protective activity of conventional antiepileptic drugs against maximal electroshock-induced seizures in mice.
Anticonvulsant profile of caprylic acid, a main constituent of the medium-chain triglyceride (MCT) ketogenic diet, in mice
Arachidonyl-2'-chloroethylamide, a highly selective cannabinoid CB1 receptor agonist, enhances the anticonvulsant action of valproate in the mouse maximal electroshock-induced seizure model.
Zonisamide: a new antiepileptic drug.
- G. Sobieszek, K. Borowicz, Ż. Kimber-Trojnar, R. Malek, Barbara Piskorska, S. Czuczwar
- Medicine, PsychologyPolish Journal of Pharmacology
- 1 September 2003
Zonisamide (ZNS) is a new antiepileptic drug (AED) efficient in treating refractory epilepsy and its efficacy in different types of seizures was confirmed in various animal studies as well as in clinical conditions.