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SIAH2 gene

Known as: Seven in Absentia Homolog 2 (Drosophila) Gene, SEVEN IN ABSENTIA, DROSOPHILA, HOMOLOG OF, 2, SIAH2 
This gene plays a role in the regulation of protein degradation.
National Institutes of Health

Related topics

Related topics

4 relations
ApoptosisSIAH2 protein, humanSignal TransductionUbiquitination

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Overexpression of seven in absentia homolog 2 protein in human breast cancer tissues is associated with the promotion of tumor cell malignant behavior in in vitro.
Seven in absentia homolog 2 (SIAH2), a homologue of Drosophila seven in absentia (Sina), has emerged as an oncogene and plays… 
2015
2015
The Ubiquitin Ligase Siah2 Regulates Obesity-induced Adipose Tissue Inflammation
Chronic, low‐grade adipose tissue inflammation associated with adipocyte hypertrophy is an important link in the relationship… 
2014
2014
Investigating the Molecular Basis of Siah1 and Siah2 E3 Ubiquitin Ligase Substrate Specificity
The Siah1 and Siah2 E3 ubiquitin ligases play an important role in diverse signaling pathways and have been shown to be… 
2013
2013
A Common Variant in the SIAH2 Locus Is Associated with Estrogen Receptor-Positive Breast Cancer in the Chinese Han Population
Background Genome-wide association studies (GWAS) have identified many loci associated with breast cancer risk. These studies… 
2013
2013
The E3 ubiquitin ligase SIAH2 is a prosurvival factor overexpressed in oral cancer.
BACKGROUND This study aimed at investigating the expression and functional significance of seven in absentia homologues 2 (SIAH2… 
2013
2013
The ubiquitin ligase Siah2 is revealed as an accomplice of the androgen receptor in castration resistant prostate cancer.
The androgen receptor (AR) remains the primary molecular target for prostate cancer (PCa) treatment and for development of novel… 
Highly Cited
2011
Highly Cited
2011
Identification of a Src Tyrosine Kinase/SIAH2 E3 Ubiquitin Ligase Pathway That Regulates C/EBPδ Expression and Contributes to Transformation of Breast Tumor Cells
ABSTRACT The transcription factor CCAAT/enhancer-binding protein delta (C/EBPδ, CEBPD) is a tumor suppressor that is… 
2011
2011
Homology modeling and in silico screening of inhibitors for the substrate binding domain of human Siah2: implications for hypoxia-induced cancers
The three-dimensional (3D) structure of the substrate binding domain (SBD) of human ubiquitin ligase Siah2 (seven in absentia… 
2010
2010
Regulation of MYPT1 stability by the E3 ubiquitin ligase SIAH2.
2007
2007
Regulation of repp86 stability by human Siah2.
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