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SHPRH gene

Known as: SNF2, LINKER HISTONE, PHD FINGER, RING FINGER, AND HELICASE DOMAINS-CONTAINING PROTEIN, bA545I5.2, SHPRH 
 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Genes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis
Circular RNAs (circRNAs) are recognized as functional non-coding transcripts in eukaryotic cells. Recent evidence has indicated… Expand
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Review
2017
Review
2017
Regulation of DNA damage tolerance in mammalian cells by post-translational modifications of PCNA.
DNA damage tolerance pathways, which include translesion DNA synthesis (TLS) and template switching, are crucial for prevention… Expand
2017
2017
SHPRH regulates rRNA transcription by recognizing the histone code in an mTOR-dependent manner
Significance Transcription of ribosomal RNA (rRNA), which composes the ribosome with other proteins, is tightly regulated to… Expand
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2016
2016
Axitinib blocks Wnt/β-catenin signaling and directs asymmetric cell division in cancer
  • Y. Qu, N. Gharbi, +9 authors X. Ke
  • Proceedings of the National Academy of Sciences
  • 2016
    • Corpus ID: 7530593
Significance The Wnt (wingless)/β-catenin signaling pathway is an attractive target for cancer therapy. However, known Wnt… Expand
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Highly Cited
2011
Highly Cited
2011
SHPRH and HLTF act in a damage-specific manner to coordinate different forms of postreplication repair and prevent mutagenesis.
Postreplication repair (PRR) pathways play important roles in restarting stalled replication forks and regulating mutagenesis. In… Expand
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Highly Cited
2011
Highly Cited
2011
HLTF and SHPRH are not essential for PCNA polyubiquitination, survival and somatic hypermutation: existence of an alternative E3 ligase.
DNA damage tolerance is regulated at least in part at the level of proliferating cell nuclear antigen (PCNA) ubiquitination… Expand
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Review
2010
Review
2010
Role of yeast Rad5 and its human orthologs, HLTF and SHPRH in DNA damage tolerance.
In the yeast Saccharomyces cerevisiae, the Rad6-Rad18 DNA damage tolerance pathway constitutes a major defense system against… Expand
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Highly Cited
2008
Highly Cited
2008
Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks
Chronic stalling of DNA replication forks caused by DNA damage can lead to genomic instability. Cells have evolved lesion bypass… Expand
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Highly Cited
2006
Highly Cited
2006
Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination
Differential modifications of proliferating cell nuclear antigen (PCNA) determine DNA repair pathways at stalled replication… Expand
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Highly Cited
2006
Highly Cited
2006
Human SHPRH is a ubiquitin ligase for Mms2–Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen
Human SHPRH gene is located at the 6q24 chromosomal region, and loss of heterozygosity in this region is seen in a wide variety… Expand
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