SHPRH gene

Circular RNAs (circRNAs) are recognized as functional non-coding transcripts in eukaryotic cells. Recent evidence has indicated… (More)

There are hundreds of copies of rDNA repeats in mammalian chromosomes and the ratio of active, poised, or inactive rDNA is… (More)

Many DNA repair proteins have additional functions other than their roles in DNA repair. In addition to catalyzing PCNA… (More)

DNA damage tolerance pathways, which include translesion DNA synthesis (TLS) and template switching, are crucial for prevention… (More)

Oncogenic mutations of the Wnt (wingless)/β-catenin pathway are frequently observed in major cancer types. Thus far, however, no… (More)

During replication, bypass of DNA lesions is orchestrated by the Rad6 pathway. Monoubiquitination of proliferating cell nuclear… (More)

Postreplication repair (PRR) pathways play important roles in restarting stalled replication forks and regulating mutagenesis. In… (More)

Chronic stalling of DNA replication forks caused by DNA damage can lead to genomic instability. Cells have evolved lesion bypass… (More)

In yeast, DNA damage leads to the mono and polyubiquitination of the sliding clamp PCNA. Monoubiquitination of PCNA is controlled… (More)