FAQ

SH-053-2'F-R-CH3

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2008-2015
02420082015

Related topics

Related topics

3 relations

Broader (2)

DiazepamImidazoles
analogs & derivatives

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
SH-053-2'F-R-CH3
Diazepam
Imidazoles
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Behavioral effects of the benzodiazepine-positive allosteric modulator SH-053-2'F-S-CH₃ in an immune-mediated neurodevelopmental disruption model.
BACKGROUND Impaired γ-aminobutyric acid (GABA) signaling may contribute to the emergence of cognitive deficits and subcortical… (More)
Is this relevant?
2015
2015
Behavioral Effects of the Benzodiazepine-Positive Allosteric Modulator SH-053-2’F-S-CH3 in an Immune-Mediated Neurodevelopmental Disruption Model
Background: Impaired γ-aminobutyric acid (GABA) signaling may contribute to the emergence of cognitive deficits and subcortical… (More)
Is this relevant?
2015
2015
Selective targeting of the α5-subunit of GABAA receptors relaxes airway smooth muscle and inhibits cellular calcium handling.
The clinical need for novel bronchodilators for the treatment of bronchoconstrictive diseases remains a major medical issue… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 5
  • figure 4
Is this relevant?
2013
2013
Prenatal immune activation induces maturation-dependent alterations in the prefrontal GABAergic transcriptome, cognitive impairments and dopaminergic hyperfunction: modulation by the benzodiazepine…
Cortical GABAergic abnormalities have been widely documented in neuropsychiatric disorders with prenatal infectious etiologies… (More)
Is this relevant?
2013
2013
Allosteric Modulation of GABAA Receptor Subtypes: Effects on Visual Recognition and Visuospatial Working Memory in Rhesus Monkeys
Non-selective positive allosteric modulators (PAMs) of GABAA receptors (GABAARs) are known to impair anterograde memory. The role… (More)
  • table 1
  • figure 1
  • figure 2
  • table 2
  • table 3
Is this relevant?
2011
2011
A Novel α5GABAAR-Positive Allosteric Modulator Reverses Hyperactivation of the Dopamine System in the MAM Model of Schizophrenia
We have shown previously that aberrant hippocampal (HPC) output underlies the dopamine (DA) dysfunction observed in the… (More)
  • figure 2
  • figure 1
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2011
2011
Lifelong CRF overproduction is associated with altered gene expression and sensitivity of discrete GABAA and mGlu receptor subtypes
Repeated activation of corticotropin-releasing factor (CRF) receptors is associated with increased anxiety and enhanced stress… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2010
2010
Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure.
Conflict procedures can be used to study the receptor mechanisms underlying the anxiolytic effects of benzodiazepines and other… (More)
Is this relevant?
2010
2010
Novel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects…
Over the last years, genetic studies have greatly improved our knowledge on the receptor subtypes mediating various… (More)
Is this relevant?
2008
2008
PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats.
Benzodiazepine (BZ) site ligands affect vigilance, anxiety, memory processes, muscle tone and epileptogenic propensity through… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
  • figure 5
Is this relevant?