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SH-053-2'F-R-CH3

 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

DiazepamImidazoles
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABAA Receptor Positive Allosteric Modulator
Rationale: Current first-line treatments for stress-related disorders such as major depressive disorder (MDD) act on… Expand
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2015
2015
Behavioral Effects of the Benzodiazepine-Positive Allosteric Modulator SH-053-2’F-S-CH3 in an Immune-Mediated Neurodevelopmental Disruption Model
Background: Impaired γ-aminobutyric acid (GABA) signaling may contribute to the emergence of cognitive deficits and subcortical… Expand
2013
2013
Enhancing the function of alpha5-subunit-containing GABAA receptors promotes action potential firing of neocortical neurons during up-states.
Neocortical neurons mediate the sedative and anticonvulsant properties of benzodiazepines. These agents enhance synaptic… Expand
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2013
2013
Allosteric Modulation of GABAA Receptor Subtypes: Effects on Visual Recognition and Visuospatial Working Memory in Rhesus Monkeys
Correction to: Neuropsychopharmacology advance online publication, 26 June 2013; doi:10.1038/npp.2013.137 In this article, there… Expand
Highly Cited
2011
Highly Cited
2011
A Novel α5GABAAR-Positive Allosteric Modulator Reverses Hyperactivation of the Dopamine System in the MAM Model of Schizophrenia
We have shown previously that aberrant hippocampal (HPC) output underlies the dopamine (DA) dysfunction observed in the… Expand
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2011
2011
Lifelong CRF overproduction is associated with altered gene expression and sensitivity of discrete GABAA and mGlu receptor subtypes
RationaleRepeated activation of corticotropin-releasing factor (CRF) receptors is associated with increased anxiety and enhanced… Expand
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2011
2011
GABA A alpha-5 subunit manipulation of maternal separation-induced anxiety in mice
Rodent models were used to examine the role of alpha-5 subunit containing GABAA receptors in modulating anxiety-like behavior… Expand
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2010
2010
Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure
Conflict procedures can be used to study the receptor mechanisms underlying the anxiolytic effects of benzodiazepines and other… Expand
2010
2010
Novel positive allosteric modulators of GABAA receptors: Do subtle differences in activity at α1 plus α5 versus α2 plus α3 subunits account for dissimilarities in behavioral effects in rats?
Over the last years, genetic studies have greatly improved our knowledge on the receptor subtypes mediating various… Expand
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Highly Cited
2008
Highly Cited
2008
PWZ-029, a compound with moderate inverse agonist functional selectivity at GABAA receptors containing α5 subunits, improves passive, but not active, avoidance learning in rats
Benzodiazepine (BZ) site ligands affect vigilance, anxiety, memory processes, muscle tone and epileptogenic propensity through… Expand
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