SH-053-2'F-R-CH3
National Institutes of Health
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A series of novel imidazobenzodiazepine analogs of the lead chiral ligand SH-053-2'F-S-CH3 (2), an α2/α3/α5 (Bz)GABA (A)ergic…
Rationale: Current first-line treatments for stress-related disorders such as major depressive disorder (MDD) act on…
Background: Impaired γ-aminobutyric acid (GABA) signaling may contribute to the emergence of cognitive deficits and subcortical…
We have shown previously that aberrant hippocampal (HPC) output underlies the dopamine (DA) dysfunction observed in the…
Repeated activation of corticotropin-releasing factor (CRF) receptors is associated with increased anxiety and enhanced stress…
Rodent models were used to examine the role of alpha-5 subunit containing GABAA receptors in modulating anxiety-like behavior…