Skip to search formSkip to main contentSkip to account menu

SH-053-2'F-R-CH3

National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

DiazepamImidazoles
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Synthesis of chiral GABAA receptor subtype selective ligands as potential agents to treat schizophrenia as well as depression.
A series of novel imidazobenzodiazepine analogs of the lead chiral ligand SH-053-2'F-S-CH3 (2), an α2/α3/α5 (Bz)GABA (A)ergic… 
Highly Cited
2016
Highly Cited
2016
Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABAA Receptor Positive Allosteric Modulator
Rationale: Current first-line treatments for stress-related disorders such as major depressive disorder (MDD) act on… 
2015
2015
Behavioral Effects of the Benzodiazepine-Positive Allosteric Modulator SH-053-2’F-S-CH3 in an Immune-Mediated Neurodevelopmental Disruption Model
Background: Impaired γ-aminobutyric acid (GABA) signaling may contribute to the emergence of cognitive deficits and subcortical… 
2013
2013
Enhancing the function of alpha5-subunit-containing GABAA receptors promotes action potential firing of neocortical neurons during up-states.
Highly Cited
2011
Highly Cited
2011
A Novel α5GABAAR-Positive Allosteric Modulator Reverses Hyperactivation of the Dopamine System in the MAM Model of Schizophrenia
We have shown previously that aberrant hippocampal (HPC) output underlies the dopamine (DA) dysfunction observed in the… 
2011
2011
Lifelong CRF overproduction is associated with altered gene expression and sensitivity of discrete GABAA and mGlu receptor subtypes
Repeated activation of corticotropin-releasing factor (CRF) receptors is associated with increased anxiety and enhanced stress… 
2011
2011
GABA A alpha-5 subunit manipulation of maternal separation-induced anxiety in mice
Rodent models were used to examine the role of alpha-5 subunit containing GABAA receptors in modulating anxiety-like behavior… 
Highly Cited
2010
Highly Cited
2010
Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure
2010
2010
Novel positive allosteric modulators of GABAA receptors: Do subtle differences in activity at α1 plus α5 versus α2 plus α3 subunits account for dissimilarities in behavioral effects in rats?
Highly Cited
2008
Highly Cited
2008
PWZ-029, a compound with moderate inverse agonist functional selectivity at GABAA receptors containing α5 subunits, improves passive, but not active, avoidance learning in rats
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)