• Publications
  • Influence
Essential Roles for the Abl and Arg Tyrosine Kinases in Neurulation
The Abl and Arg tyrosine kinases play fundamental roles in the development and function of the central nervous system. Arg is most abundant in adult mouse brain, especially in synapse-rich regions.Expand
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Persistent escalation of alcohol drinking in C57BL/6J mice with intermittent access to 20% ethanol.
BACKGROUND Intermittent access (IA) to drugs of abuse, as opposed to continuous access, is hypothesized to induce a kindling-type transition from moderate to escalated use, leading to dependence.Expand
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Social defeat stress selectively alters mesocorticolimbic dopamine release: an in vivo microdialysis study
Exposure to various aversive stimuli ('stressors') as well as positively-reinforcing stimuli has been shown to increase extracellular dopamine concentrations in terminal areas of theExpand
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Social stress, therapeutics and drug abuse: preclinical models of escalated and depressed intake.
The impact of ostensibly aversive social stresses on triggering, amplifying and prolonging intensely rewarding drug taking is an apparent contradiction in need of resolution. Social stressExpand
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Repeated social-defeat stress, cocaine or morphine
Abstract.Rationale: Repeated social stress experiences engender "behavioral sensitization" and may also increase the potential for abuse of psychomotor stimulants, particularly cocaine use duringExpand
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Escalated or Suppressed Cocaine Reward, Tegmental BDNF, and Accumbal Dopamine Caused by Episodic versus Continuous Social Stress in Rats
The neural link between ostensibly aversive stress experiences and intensely rewarding drug taking remains to be delineated. Epidemiological data associate stress and the abuse of various drugs, andExpand
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A new test for aggression in rats without aversive stimulation: Differential effects of d-amphetamine and cocaine
  • K. Miczek
  • Psychology, Medicine
  • Psychopharmacology
  • 28 February 1979
A procedure has been developed which reliably engenders agonistic behavior between alpha males of small colonies of laboratory rats and intruder rats. Drugs were administered either to the alphaExpand
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Understanding and Preventing Violence
By conservative estimates, more than 16,000 violent crimes are committed or attempted every day in the United States. Violence involves many factors and spurs many viewpoints, and this diversityExpand
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Acquisition of cocaine self-administration after social stress: role of accumbens dopamine
Abstract Exposure to either aversive or rewarding environmental stimuli increases extracellular dopamine (DA) concentrations in terminal areas of the mesocorticolimbic dopamine system. Furthermore,Expand
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Increased phasic dopamine signaling in the mesolimbic pathway during social defeat in rats
While reward-dependent facilitation of phasic dopamine signaling is well documented at both the cell bodies and terminals, little is known regarding fast dopamine transmission under aversiveExpand
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