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SGI 1776

Known as: SGI-1776, SGI1776 
National Institutes of Health

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2 relations

Broader (2)

ImidazolesPyridazines

Papers overview

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2020
2020
Anti‐tumour effects of PIM kinase inhibition on progression and chemoresistance of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a biologically aggressive cancer. Targeted therapy is in need to tackle challenges in the… 
2019
2019
Inhibition of PIM1 blocks the autophagic flux to sensitize glioblastoma cells to ABT-737-induced apoptosis.
2016
2016
Targeting of glioblastoma cell lines and glioma stem cells by combined PIM kinase and PI3K-p110α inhibition
The PIM family of proteins encodes serine/threonine kinases with important roles in protein synthesis and cancer cell metabolism… 
2015
2015
Pre-clinical evidence of PIM kinase inhibitor activity in BCR-ABL1 unmutated and mutated Philadelphia chromosome-positive (Ph+) leukemias
We investigated the efficacy of targeting the PIM kinase pathway in Philadelphia chromosome-positive (Ph+) leukemias. We provide… 
2013
2013
Biological effects of the Pim kinase inhibitor, SGI-1776, in multiple myeloma.
2012
2012
Studying c-Myc serine 62 phosphorylation in leukemia cells: concern over antibody cross-reactivity.
To the editor: A recent article in Blood demonstrated that the Pim kinase inhibitor SGI-1776 has efficacy in acute myeloid… 
2011
2011
PIM kinase isoform specific regulation of MIG6 expression and EGFR signaling in prostate cancer cells
The PIM family of oncogenic serine/threonine kinases regulates tumour cell proliferation. To identify proliferative signaling… 
2011
2011
Targeting PIM kinase enhances the activity of sunitinib in renal cell carcinoma
Background:Upregulation of PIM kinase expression has been reported in many malignancies, suggesting that inhibition of PIM kinase… 
2009
2009
Synergistic Activity of Co-Treatment with PIM1 Kinase Inhibitor SGI-1776 and Histone Deacetylase Inhibitor Panobinostat or Heat Shock Protein 90 Inhibitor AUY922 against Human CML and…
Abstract 2651 Poster Board II-627 The oncoprotein PIM1 is a cytoplasmic serine/threonine kinase, which is overexpressed and… 
2008
2008
Progress in Applying HPC to Support Operational Use of CT-Analyst
The objective of this effort is to perform the research and development (R&D) and systems engineering necessary to integrate… 
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