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SGI 1776

Known as: SGI-1776, SGI1776 
 
National Institutes of Health

Papers overview

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2013
2013
Overexpression of the ATP-binding cassette (ABC) drug efflux proteins P-glycoprotein (ABCB1) and breast cancer resistance protein… Expand
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2013
2013
BACKGROUND Pim kinases are constitutively active serine/threonine/tyrosine kinases that are overexpressed in hematological… Expand
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2012
2012
Proviral integration site for Moloney murine leukemia virus (Pim) kinases are serine/threonine/tyrosine kinases and oncoproteins… Expand
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2012
2012
The PIM kinase inhibitor, SGI-1776, was tested against the PPTP in vitro (1.0 nM-10 µM) and in vivo panels (148 mg/kg daily × 5… Expand
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2012
2012
miRs play a critical role in tumor pathogenesis as either oncogenes or tumor-suppressor genes. However, the role of miRs and… Expand
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2012
2012
To the editor: The Pim (for provirus integration site for Moloney murine leukemia virus) family of serine/threonine kinases are… Expand
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Highly Cited
2011
Highly Cited
2011
Pim kinases are Ser/Thr kinases with multiple substrates that affect survival pathways. These proteins are overexpressed in acute… Expand
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Review
2011
Review
2011
Pulmonary arterial hypertension (PAH) is a disease of the pulmonary vasculature characterized by constricted and remodeled… Expand
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Highly Cited
2009
Highly Cited
2009
Pim kinases are involved in B-cell development and are overexpressed in B-cell chronic lymphocytic leukemia (CLL). We… Expand
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Highly Cited
2009
Highly Cited
2009
The serine/threonine family of Pim kinases function as oncogenes and have been implicated in prostate cancer progression… Expand
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