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SFN wt Allele

Known as: Stratifin wt Allele, HME1, 14-3-3 Sigma Gene 
Human SFN wild-type allele is located in the vicinity of 1p36.11 and is approximately 1 kb in length. This allele, which encodes 14-3-3 protein sigma… Expand
National Institutes of Health

Related topics

Related topics

4 relations
1p35.3Cell Cycle ControlEFP Cell Cycle PathwayNegative Regulation of Cell Cycle

Papers overview

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2009
2009
Inactivation of 14-3-3 sigma by promoter methylation correlates with metastasis in nasopharyngeal carcinoma.
14-3-3 sigma, the downstream target of p53, is a negative regulator of cell cycle G2-M phase checkpoint in response to DNA damage… Expand
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2008
2008
Different mutant/wild-type p53 combinations cause a spectrum of increased invasive potential in nonmalignant immortalized human mammary epithelial cells.
Aberrations of p53 occur in most, if not all, human cancers. In breast cancer, p53 mutation is the most common genetic defect… Expand
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2006
2006
Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas.
To explore the significance of epigenetic mechanisms in urinary bladder carcinogenesis mediated by methylation of cytosine in CpG… Expand
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2005
2005
Expression of endothelins and their receptors promotes an invasive phenotype of breast tumor cells but is insufficient to induce invasion in benign cells.
There is increased staining of endothelins (ET-1, -2, and -3) and receptors (ET-RA and -RB) in invasive breast tumors compared to… Expand
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Highly Cited
2004
Highly Cited
2004
Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-alpha dependent up-regulation of matrix metalloproteases.
Apart from the neoplastic cells, malignant tumours consist of the extracellular matrix (ECM) and normal cells, in particular… Expand
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Highly Cited
2004
Highly Cited
2004
Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: its correlation with aberrant DNA methylation.
PURPOSE In this study, we examined the promoter methylation status and expression of 14-3-3 sigma and evaluated its clinical… Expand
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Highly Cited
2002
Highly Cited
2002
Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell…
Caveolin-1 (Cav-1) is the principal structural protein of caveolae membranes that are found in most cells types, including… Expand
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Highly Cited
2000
Highly Cited
2000
Inactivation of the 14-3-3 sigma gene is associated with 5' CpG island hypermethylation in human cancers.
The cell cycle checkpoint plays an important role in maintaining the integrity of cells. Recently, one of the 14-3-3 protein… Expand
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Highly Cited
1996
Highly Cited
1996
Molecular evolution of the 14-3-3 protein family
Members of the highly conserved and ubiquitous 14-3-3 protein family modulate a wide variety of cellular processes. To determine… Expand
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Highly Cited
1992
Highly Cited
1992
Complementary DNA cloning of a novel epithelial cell marker protein, HME1, that may be down-regulated in neoplastic mammary cells.
A full-length complementary DNA clone from a normal human mammary epithelial cell (strain 184) encoding a 25-kilodalton protein… Expand
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