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SFN wt Allele

Known as: Stratifin wt Allele, HME1, 14-3-3 Sigma Gene 
Human SFN wild-type allele is located in the vicinity of 1p36.11 and is approximately 1 kb in length. This allele, which encodes 14-3-3 protein sigma… Expand
National Institutes of Health

Related topics

Related topics

4 relations
1p35.3Cell Cycle ControlEFP Cell Cycle PathwayNegative Regulation of Cell Cycle

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Inactivation of 14‐3‐3 σ by promoter methylation correlates with metastasis in nasopharyngeal carcinoma
14‐3‐3 σ, the downstream target of p53, is a negative regulator of cell cycle G2‐M phase checkpoint in response to DNA damage… Expand
Highly Cited
2008
Highly Cited
2008
Different mutant/wild-type p53 combinations cause a spectrum of increased invasive potential in nonmalignant immortalized human mammary epithelial cells.
Aberrations of p53 occur in most, if not all, human cancers. In breast cancer, p53 mutation is the most common genetic defect… Expand
Highly Cited
2006
Highly Cited
2006
Molecular evolution of the 14-3-3 protein family
Members of the highly conserved and ubiquitous 14-3-3 protein family modulate a wide variety of cellular processes. To determine… Expand
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2006
2006
Promoter hypermethylation of the 14-3-3 sigma, SYK and CAGE-1 genes is related to the various phenotypes of urinary bladder carcinomas and associated with progression of transitional cell carcinomas.
To explore the significance of epigenetic mechanisms in urinary bladder carcinogenesis mediated by methylation of cytosine in CpG… Expand
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Highly Cited
2004
Highly Cited
2004
Enhanced invasiveness of breast cancer cell lines upon co-cultivation with macrophages is due to TNF-alpha dependent up-regulation of matrix metalloproteases.
Apart from the neoplastic cells, malignant tumours consist of the extracellular matrix (ECM) and normal cells, in particular… Expand
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Highly Cited
2004
Highly Cited
2004
Decreased expression of 14-3-3 sigma is associated with advanced disease in human epithelial ovarian cancer: its correlation with aberrant DNA methylation.
PURPOSE In this study, we examined the promoter methylation status and expression of 14-3-3 sigma and evaluated its clinical… Expand
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Highly Cited
2004
Highly Cited
2004
Expression and methylation status of 14-3-3 sigma gene can characterize the different histological features of ovarian cancer.
We hypothesize that 14-3-3 sigma gene expression and its regulation by methylation can characterize histological types of primary… Expand
Highly Cited
2002
Highly Cited
2002
Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell…
Caveolin-1 (Cav-1) is the principal structural protein of caveolae membranes that are found in most cells types, including… Expand
Highly Cited
2000
Highly Cited
2000
Inactivation of the 14-3-3 sigma gene is associated with 5' CpG island hypermethylation in human cancers.
The cell cycle checkpoint plays an important role in maintaining the integrity of cells. Recently, one of the 14-3-3 protein… Expand
Highly Cited
1992
Highly Cited
1992
Complementary DNA cloning of a novel epithelial cell marker protein, HME1, that may be down-regulated in neoplastic mammary cells.
A full-length complementary DNA clone from a normal human mammary epithelial cell (strain 184) encoding a 25-kilodalton protein… Expand
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