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SEMA4D protein, human

Known as: M-Sema-G, C9orf164, CD100 antigen, human 
Semaphorin-4D (862 aa, ~96 kDa) is encoded by the human SEMA4D gene. This protein is involved in both axonal growth cone guidance in the developing… Expand
National Institutes of Health

Related topics

Related topics

4 relations

Broader (1)

CD100 antigen
SEMA4D geneSignal TransductionSignaling Pathway Gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Bone scaffolds loaded with siRNA-Semaphorin4d for the treatment of osteoporosis related bone defects
Osteoporosis is a prominent disorder affecting over 200 million people worldwide. Recently, semaphorins have been implicated in… Expand
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2016
2016
Plexin-B1 signalling promotes androgen receptor translocation to the nucleus
Semaphorins and their receptors plexins have diverse roles in many cancers affecting tumour growth, metastasis and angiogenesis… Expand
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Highly Cited
2015
Highly Cited
2015
Anabolic Bone Formation Via a Site‐Specific Bone‐Targeting Delivery System by Interfering With Semaphorin 4d Expression
Semaphorins have been recently targeted as new molecules directly implicated in the cell‐cell communication that occurs between… Expand
2014
2014
Hypoxia-inducible factor-1α and semaphorin4D genes involved with tumor-associated macrophage-induced metastatic behavior and clinical significance in colon cancer.
BACKGROUND Hypoxia promotes tumor angiogenesis and hypoxia-inducible factor-1 alpha (HIF-1α) plays a pivotal role in this process… Expand
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2013
2013
Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses vasculogenic mimicry and proliferation of highly aggressive pancreatic cancer PaTu8988 cells
BackgroundPancreatic cancer is one of the most aggressive human malignancies with a extremely low 5-year survival rate. Hence… Expand
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2012
2012
Grb2 mediates semaphorin-4D-dependent RhoA inactivation
Summary Signaling through the semaphorin 4D (Sema4D) receptor plexin-B1 is modulated by its interaction with tyrosine kinases… Expand
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2012
2012
Over-Expression of Semaphorin4D, Hypoxia-Inducible Factor-1α and Vascular Endothelial Growth Factor Is Related to Poor Prognosis in Ovarian Epithelial Cancer
Semaphorin4D (SEMA4D) has been regarded as an important protein in tumor angiogenesis, though originally identified in… Expand
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Highly Cited
2008
Highly Cited
2008
Semaphorin 4D regulates gonadotropin hormone–releasing hormone-1 neuronal migration through PlexinB1–Met complex
In mammals, reproduction is dependent on specific neurons secreting the neuropeptide gonadotropin hormone–releasing hormone-1… Expand
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Review
2007
Review
2007
Semaphorin signaling in vascular and tumor biology.
The neuropilins were originally characterized as cell membrane receptors that bind axon guidance factors belonging to the class-3… Expand
Highly Cited
2002
Highly Cited
2002
The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding.
The small GTPase Rac has been implicated in growth cone guidance mediated by semaphorins and their receptors. Here we demonstrate… Expand
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