FAQ

SDHD protein, human

Known as: Mitochondrial Complex II, Respiratory Complex II, succinate dehydrogenase complex, subunit D, integral membrane protein, human 
A heterotetrameric enzyme complex found in the inner mitochondrial membrane. This protein complex catalyzes the oxidation of succinate and reduction… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1943-2018
010020019432017

Related topics

Related topics

14 relations
Cell RespirationInner mitochondrial membraneIonophore activityOxidation-Reduction
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Broader (2)

Electron Transport Complex IISuccinate Dehydrogenase

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
SDHD protein, human
Oxidation-Reduction
Oxidoreductase
Cell Respiration
Inner mitochondrial membrane
Succinate Dehydrogenase

Papers overview

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Highly Cited
2014
Highly Cited
2014
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
Ischaemia-reperfusion injury occurs when the blood supply to an organ is disrupted and then restored, and underlies many… (More)
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Highly Cited
2008
Highly Cited
2008
Clinical and molecular genetics of patients with the Carney–Stratakis syndrome and germline mutations of the genes coding for the succinate dehydrogenase subunits SDHB, SDHC, and SDHD
Gastrointestinal stromal tumors (GISTs) may be caused by germline mutations of the KIT and platelet-derived growth factor… (More)
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Highly Cited
2005
Highly Cited
2005
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase.
Several mitochondrial proteins are tumor suppressors. These include succinate dehydrogenase (SDH) and fumarate hydratase, both… (More)
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Highly Cited
2005
Highly Cited
2005
Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations.
The nuclear-encoded Krebs cycle enzymes, fumarate hydratase (FH) and succinate dehydrogenase (SDHB, -C and -D), act as tumour… (More)
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Highly Cited
2003
Highly Cited
2003
Architecture of succinate dehydrogenase and reactive oxygen species generation.
The structure of Escherichia coli succinate dehydrogenase (SQR), analogous to the mitochondrial respiratory complex II, has been… (More)
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Highly Cited
1996
Highly Cited
1996
Differential inhibitory action of nitric oxide and peroxynitrite on mitochondrial electron transport.
Various authors have suggested that nitric oxide (.NO) exerts cytotoxic effects through the inhibition of cellular respiration… (More)
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Highly Cited
1995
Highly Cited
1995
Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase
The Sod2 gene for Mn–superoxide dismutase (MnSOD), an intramitochondrial free radical scavenging enzyme that is the first line of… (More)
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Highly Cited
1994
Highly Cited
1994
Inhibition of mitochondrial electron transport by peroxynitrite.
Mammalian mitochondria are sensitive targets of the cytotoxic effects of superoxide (O.2-) and nitric oxide (.NO). In turn, when… (More)
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Highly Cited
1990
Highly Cited
1990
Skeletal muscle biochemistry and histology in ambulatory patients with long-term heart failure.
Recent studies in patients with long-term heart failure have suggested that intrinsic abnormalities in skeletal muscle can… (More)
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Highly Cited
1957
Highly Cited
1957
Cytochemical demonstration of succinic dehydrogenase by the use of a new p-nitrophenyl substituted ditetrazole.
 
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