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SDHD protein, human

Known as: Mitochondrial Complex II, Respiratory Complex II, succinate dehydrogenase complex, subunit D, integral membrane protein, human 
A heterotetrameric enzyme complex found in the inner mitochondrial membrane. This protein complex catalyzes the oxidation of succinate and reduction… Expand
National Institutes of Health

Related topics

Related topics

16 relations
Cell RespirationInner mitochondrial membraneIonophore activityOxidation-Reduction
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Broader (2)

Electron Transport Complex IISuccinate Dehydrogenase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages
Activated macrophages undergo metabolic reprogramming, which drives their pro-inflammatory phenotype, but the mechanistic basis… Expand
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Highly Cited
2016
Highly Cited
2016
Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation.
Remodeling of the tricarboxylic acid (TCA) cycle is a metabolic adaptation accompanying inflammatory macrophage activation… Expand
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Highly Cited
2014
Highly Cited
2014
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS
Ischaemia-reperfusion injury occurs when the blood supply to an organ is disrupted and then restored, and underlies many… Expand
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Highly Cited
2005
Highly Cited
2005
Crystal Structure of Mitochondrial Respiratory Membrane Protein Complex II
The mitochondrial respiratory Complex II or succinate:ubiquinone oxidoreductase (SQR) is an integral membrane protein complex in… Expand
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Highly Cited
2003
Highly Cited
2003
Architecture of Succinate Dehydrogenase and Reactive Oxygen Species Generation
The structure of Escherichia colisuccinate dehydrogenase (SQR), analogous to the mitochondrial respiratory complex II, has been… Expand
Highly Cited
2001
Highly Cited
2001
The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway.
Hereditary paragangliomas are usually benign tumors of the autonomic nervous system that are composed of cells derived from the… Expand
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Highly Cited
1998
Highly Cited
1998
A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes
Much attention has focused on the aetiology of oxidative damagein cellular and organismal ageing. Especially toxic arethe… Expand
Highly Cited
1995
Highly Cited
1995
Mutation of a nuclear succinate dehydrogenase gene results in mitochondrial respiratory chain deficiency
We now report a mutation in the nuclear–encoded flavoprotein (Fp) subunit gene of the succinate dehydrogenase (SDH) in two… Expand
Highly Cited
1976
Highly Cited
1976
Role of ubiquinone in the mitochondrial generation of hydrogen peroxide.
Antimycin-inhibited bovine heart submitochondrial particles generate O2- and H2O2 with succinate as electron donor. H2O2… Expand
Highly Cited
1973
Highly Cited
1973
Peroxisomal and Mitochondrial Defects in the Cerebro-Hepato-Renal Syndrome
The cerebro-hepato-renal syndrome is a rare familial malady with cerebral, renal, and skeletal abnormalities, severe hypotonia… Expand
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