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Architecture of the Photosynthetic Oxygen-Evolving Center
The data strongly suggest that the OEC contains a cubane-like Mn3CaO4 cluster linked to a fourth Mn by a mono-μ-oxo bridge, and the details of the surrounding coordination sphere of the metal cluster and the implications for a possible oxygen-evolving mechanism are discussed.
Structure of the Escherichia coli fumarate reductase respiratory complex.
The crystal structure of intact fumarate reductase has been solved at 3.3 angstrom resolution and demonstrates that the cofactors are arranged in a nearly linear manner from the membrane-bound quinone to the active site flavin.
A Ni-Fe-Cu Center in a Bifunctional Carbon Monoxide Dehydrogenase/ Acetyl-CoA Synthase
A metallocofactor containing iron, sulfur, copper, and nickel has been discovered in the enzyme carbon monoxide dehydrogenase/acetyl-CoA (coenzyme A) synthase from Moorella thermoacetica and suggests a newly discovered role for copper in biology.
A closer look at the active site of gamma-class carbonic anhydrases: high-resolution crystallographic studies of the carbonic anhydrase from Methanosarcina thermophila.
The prototype of the γ-class of carbonic anhydrase has been characterized from the methanogenic archaeon Methanosarcina thermophila. Previously reported kinetic studies of the γ-class carbonic
Catalytic mechanisms of complex II enzymes: a structural perspective.
  • T. Iverson
  • Chemistry, Medicine
    Biochimica et biophysica acta
  • 1 May 2013
This review focuses on how structural data have augmented the authors' understanding of catalysis by the complex II superfamily, and how these structures have contributed to detailed proposals for reaction mechanisms at each of the two enzyme active sites.
A biological role for prokaryotic ClC chloride channels
It is shown that Escherichia coli uses chloride channels of the widespread ClC family in the extreme acid resistance response and proposed that the channels function as an electrical shunt for an outwardly directed virtual proton pump that is linked to amino acid decarboxylation.
Crystal Structure of the “cab”-type β Class Carbonic Anhydrase from the Archaeon Methanobacterium thermoautotrophicum *
The structure of the “cab”-type β class carbonic anhydrase from the archaeon Methanobacterium thermoautotrophicum (Cab) has been determined to 2.1-Å resolution using the multiwavelength anomalous
A Structural Model for Binding of the Serine-Rich Repeat Adhesin GspB to Host Carbohydrate Receptors
The high-resolution x-ray crystal structure of the GspB binding region (GspBBR) suggests that the binding specificity of the SRR family of adhesins is determined by the type and organization of discrete modules within the binding domains, which may affect the tropism of organisms for different tissues.
Structural basis for solute transport, nucleotide regulation, and immunological recognition of Neisseria meningitidis PorB
Structural analysis and cocrystallization studies identify three putative solute translocation pathways through the channel pore and features of PorB suggest that Toll-like receptor mediated recognition outer membrane proteins may be initiated with a nonspecific electrostatic attraction.
Involvement of distinct arrestin-1 elements in binding to different functional forms of rhodopsin
It is hypothesized that complex formation with either P-Rh* or P-opsin results in a global transition in the conformation of arrestin-1, possibly to a dynamic molten globule-like structure, and contributes to the mechanism that triggers preferential interactions of several signaling proteins with receptor-activated arrestins.