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Metabolic phenotype can be affected by multiple factors, including allelic variation and interactions with inhibitors. Human… Expand Cytochrome P450 enzymes (CYPs) are a heme-containing enzyme superfamily that have a major role in the metabolism of drugs in… Expand Cytochrome P450s (CYPs) are heme-containing enzymes that metabolize small organic molecules including drugs. CYP3A4 and CYP2D6… Expand Cytochrome P450 enzymes (CYPs) represent an important enzyme superfamily involved in metabolism of many endogenous and exogenous… Expand Human cytochrome P450 3A4 (CYP3A4) is responsible for the metabolism of more than half of pharmaceutic drugs, and inactivation of… Expand Human cytochrome P450 2D6 (CYP2D6) is involved in metabolism of approximately 25% of pharmaceutical drugs. Inactivation of CYP2D6… Expand 5-Fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine (SCH 66712) is a potent mechanism-based inactivator of… Expand SCH 66712 [5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine] caused a time- and NADPH-dependent loss of… Expand SCH 66712 is a potent and selective dopamine D4 receptor antagonist. An HPLC method was developed for the analysis of SCH 66712… Expand