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SCH 66712

Known as: SCH66712 
National Institutes of Health

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2 relations

Broader (2)

ImidazolesPyrimidines

Papers overview

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2018
2018
CYP2D6 Allelic Variants *34, *17-2, *17-3, and *53 and a Thr309Ala Mutant Display Altered Kinetics and NADPH Coupling in Metabolism of Bufuralol and Dextromethorphan and Altered Susceptibility to…
Metabolic phenotype can be affected by multiple factors, including allelic variation and interactions with inhibitors. Human… 
2017
2017
CYP2D6 Allelic Variants *17-2 & 17-3 Metabolize the Same Substrates as *1 but are Less Susceptibility to Inactivation by SCH 66712
2015
2015
Interactions of Human CYP2D6 Polymorphisms with the Mechanism‐Based Inactivator SCH 66712
Cytochrome P450 enzymes (CYPs) are a heme‐containing enzyme superfamily that have a major role in the metabolism of drugs in… 
2015
2015
SCH 66712 and EMTPP are the First Potent Mechanism‐Based Inactivators of Both Human CYP2D6 and CYP3A4
Cytochrome P450s (CYPs) are heme‐containing enzymes that metabolize small organic molecules including drugs. CYP3A4 and CYP2D6… 
2014
2014
Molecular Dynamics of CYP2D6 Polymorphisms in the Absence and Presence of a Mechanism-Based Inactivator Reveals Changes in Local Flexibility and Dominant Substrate Access Channels
Cytochrome P450 enzymes (CYPs) represent an important enzyme superfamily involved in metabolism of many endogenous and exogenous… 
2012
2012
Molecular analysis and modeling of inactivation of human CYP2D6 by four mechanism based inactivators.
Human cytochrome P450 2D6 (CYP2D6) is involved in metabolism of approximately 25% of pharmaceutical drugs. Inactivation of CYP2D6… 
2011
2011
Substituted Imidazole of 5-Fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine Inactivates Cytochrome P450 2D6 by Protein Adduction
5-Fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine (SCH 66712) is a potent mechanism-based inactivator of… 
2011
2011
Use of AutoDock Modeling to Understand Inactivation of Human Cytochrome P450 2D6 by SCH 66712
AutoDock is a free‐ware program that simulates ligand‐binding to the active site of a protein based on three‐dimensional… 
2001
2001
Mechanism-based inactivation of CYP2D6 by 5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine.
SCH 66712 [5-fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine] caused a time- and NADPH-dependent loss of… 
1999
1999
High-performance liquid chromatographic analysis of the D4 receptor antagonist SCH 66712 in rat plasma.
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