Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

SCH-58500

Known as: ACN53, Recombinant Adenovirus-p53 SCH-58500, SCH 58500 
A genetically-engineered adenovirus that contains the gene that encodes the human tumor-suppressor protein p53 with potential antineoplastic activity… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
The major focus of intrahepatic arterial (IHA) administration of adenoviruses (Ad) has been on safety. Currently, there is little… Expand
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Purpose: To determine the safety, gene transfer, host immune response, and pharmacokinetics of a replication-deficient adenovirus… Expand
  • table 1
  • table 2
  • table 3
  • figure 1
  • figure 2
Is this relevant?
2002
2002
Objective: We have previously reported the safety, efficient gene transfer, and favorable CA125 responses of individuals with… Expand
  • figure 1
  • table 1
  • table 2
  • figure 2
  • table 3
Is this relevant?
2002
2002
SCH 58500 is a replication-defective recombinant adenoviral vector containing the cloned human wild-type (normal) tumor… Expand
  • table 1
  • table 2
  • table 3
  • table 4
  • table 5
Is this relevant?
2000
2000
SCH58500 (ACN53) is a recombinant adenovirus expressing human p53 for gene therapy of cancer. In preclinical studies, SCH58500… Expand
Is this relevant?
2000
2000
SCH58500 (ACN53) is a replication-deficient, type 5 adenovirus (Ad) expressing human wild-type p53 tumor suppressor. It is… Expand
Is this relevant?
2000
2000
SCH58500 (ACN53) is a replication-deficient, recombinant adenovirus which expresses human p53 tumor suppressor. In preclinical… Expand
Is this relevant?
1999
1999
Purpose: Adenovirus-mediated p53 gene therapy for cancer is currently undergoing phase I/II clinical trials. The drug used in our… Expand
  • figure 2
  • table 1
  • figure 3
  • table 2
  • figure 4
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Mutations of p53 gene are reported in 50-60% of human cancers and reintroduction of wild-type p53 can suppress cell proliferation… Expand
Is this relevant?
Highly Cited
1995
Highly Cited
1995
We have investigated the use of column chromatography for the purification of ACN53, a recombinant adenovirus type 5 encoding the… Expand
Is this relevant?