SCH-58500

Known as: ACN53, Recombinant Adenovirus-p53 SCH-58500, Sch 58500 
A genetically-engineered adenovirus that contains the gene that encodes the human tumor-suppressor protein p53 with potential antineoplastic activity… (More)

Topic mentions per year

Topic mentions per year

1995-2013
0119952013

Papers overview

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2006
2006
The major focus of intrahepatic arterial (IHA) administration of adenoviruses (Ad) has been on safety. Currently, there is little… (More)
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2002
2002
Purpose: To determine the safety, gene transfer, host immune response, and pharmacokinetics of a replication-deficient adenovirus… (More)
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2002
2002
Objective: We have previously reported the safety, efficient gene transfer, and favorable CA125 responses of individuals with… (More)
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2002
2002
Adenoviral vectors are being actively investigated for their potential utility in gene therapy. SCH 58500, a replication… (More)
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2002
2002
SCH 58500 is a replication-defective recombinant adenoviral vector containing the cloned human wild-type (normal) tumor… (More)
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2002
2002
PURPOSE To study safety, feasibility, and biologic activity of adenovirus-mediated p53 gene transfer in patients with bladder… (More)
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2001
2001
PURPOSE To study the additional benefit from adenoviral p53 gene therapy in patients undergoing first-line chemotherapy for… (More)
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1999
1999
Purpose: Adenovirus-mediated p53 gene therapy for cancer is currently undergoing phase I/II clinical trials. The drug used in our… (More)
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1996
1996
Mutations of p53 gene are reported in 50-60% of human cancers and reintroduction of wild-type p53 can suppress cell proliferation… (More)
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1995
1995
We have investigated the use of column chromatography for the purification of ACN53, a recombinant adenovirus type 5 encoding the… (More)
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