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Recombinant Adenovirus-p53

Known as: Recombinant Adenovirus Encoding p53, rAd-p53, rAd/p53 
A replication-defective, recombinant adenoviral vector encoding the wild-type human tumor-suppressor protein p53 gene with potential antineoplastic… 
National Institutes of Health

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SCH-58500

Papers overview

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2017
2017
Combination of p53-DC vaccine and rAd-p53 gene therapy induced CTLs cytotoxic against p53-deleted human prostate cancer cells in vitro
Recently, the US FDA approved sipuleucel-T, which is composed of autologous DCs stimulated with a recombinant fusion protein of… 
2016
2016
Effect and Safety of Recombinant Adenovirus-p53 Transfer Combined with Radiotherapy on Long-Term Survival of Locally Advanced Cervical Cancer.
Detection of exogenous p53 gene and target gene expression in cervical cancer cell lines SiHa and C33A infected by recombinant… 
Review
2014
Review
2014
Emerging Biological Treatments for Uterine Cervical Carcinoma
Cervical cancer is the third most common cancer worldwide, and the development of new diagnosis, prognostic, and treatment… 
Highly Cited
2013
Highly Cited
2013
Recombinant Human Adenovirus-p53 Injection Induced Apoptosis in Hepatocellular Carcinoma Cell Lines Mediated by p53-Fbxw7 Pathway, Which Controls c-Myc and Cyclin E
F-box and WD repeat domain-containing 7 (Fbxw7/hAgo/hCdc4/Fbw7) is a p53-dependent tumor suppressor and leads to ubiquitination… 
Highly Cited
2010
Highly Cited
2010
Clinical study of recombinant adenovirus-p53 combined with fractionated stereotactic radiotherapy for hepatocellular carcinoma
ObjectiveThe purpose of our study was to evaluate the feasibility and treatment outcomes of recombinant adenovirus-p53 (rAd-p53… 
2008
2008
Advanced Malignant Pleural or Peritoneal Effusion in Patients Treated with Recombinant Adenovirus p53 Injection plus Cisplatin
The aim of this study was to evaluate the efficacy of recombinant adenovirus p53 agent (rAd-p53) injection combined with… 
2002
2002
The use of field emission scanning electron microscopy to assess recombinant adenovirus stability.
A field emission scanning electron microscopy (FESEM) method was developed to assess the stability of a recombinant adenovirus… 
Highly Cited
2000
Highly Cited
2000
Calpain inhibitor 1 activates p53-dependent apoptosis in tumor cell lines.
Reports suggest a role of calpains in degradation of wild-type p53, which may regulate p53 induction of apoptosis. A calpain… 
Highly Cited
1996
Highly Cited
1996
Adenovirus-mediated p53 gene transfer inhibits growth of human tumor cells expressing mutant p53 protein.
Human malignancies are often characterized by mutations of the p53 tumor suppressor gene. In a large proportion of cases, the… 
Highly Cited
1996
Highly Cited
1996
Adenovirus‐mediated p53 gene transfer suppresses growth of human glioblastoma cells in vitro and in vivo
Alterations in the p53 tumor‐suppressor gene occur in 35–60% of human glioblastomas, and re‐introduction of p53 can suppress… 
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