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Recombinant Adenovirus-p53

Known as: Recombinant Adenovirus Encoding p53, rAd-p53, rAd/p53 
A replication-defective, recombinant adenoviral vector encoding the wild-type human tumor-suppressor protein p53 gene with potential antineoplastic… Expand
National Institutes of Health

Papers overview

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2016
2016
Detection of exogenous p53 gene and target gene expression in cervical cancer cell lines SiHa and C33A infected by recombinant… Expand
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2013
2013
F-box and WD repeat domain-containing 7 (Fbxw7/hAgo/hCdc4/Fbw7) is a p53-dependent tumor suppressor and leads to ubiquitination… Expand
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Highly Cited
2009
Highly Cited
2009
ObjectiveThe purpose of our study was to evaluate the feasibility and treatment outcomes of recombinant adenovirus-p53 (rAd-p53… Expand
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2008
2008
  • M. Dong, X. Li, +6 authors H-J Shen
  • The Journal of international medical research
  • 2008
  • Corpus ID: 27972277
The aim of this study was to evaluate the efficacy of recombinant adenovirus p53 agent (rAd-p53) injection combined with… Expand
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2002
2002
A field emission scanning electron microscopy (FESEM) method was developed to assess the stability of a recombinant adenovirus… Expand
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2001
2001
TP53 is the most commonly altered tumor-suppressor gene in cancer and is currently being tested in Phase II/III gene replacement… Expand
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Highly Cited
2000
Highly Cited
2000
Reports suggest a role of calpains in degradation of wild-type p53, which may regulate p53 induction of apoptosis. A calpain… Expand
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2000
2000
We have shown that the loss of p53 function contributed to resistance of tumor cells to TNF‐induced cytotoxicity. In the present… Expand
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Highly Cited
1996
Highly Cited
1996
Human malignancies are often characterized by mutations of the p53 tumor suppressor gene. In a large proportion of cases, the… Expand
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Highly Cited
1996
Highly Cited
1996
Alterations in the p53 tumor‐suppressor gene occur in 35–60% of human glioblastomas, and re‐introduction of p53 can suppress… Expand
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