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SCH 486757

Known as: SCH-486757, SCH486757 
National Institutes of Health

Papers overview

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2017
2017
In vitro pharmacological characterization of a novel unbiased NOP receptor‐selective nonpeptide agonist AT‐403
Nociceptin/orphanin FQ (N/OFQ) regulates several biological functions via selective activation of the N/OFQ receptor (NOP), a… 
2012
2012
Effects of SCH 486757, a nociceptin-1 receptor agonist, on fertility and reproductive hormone levels in female CRL:CD®[SD] rats.
BACKGROUND SCH 486757 is a nociceptin-1 receptor agonist that was in development as an antitussive. Studies were conducted to… 
Review
2011
Review
2011
Where Are the New Cough Treatments: A Debriefing of Recent Clinical Proof-of-Concept Trials with the NOP Agonist SCH 486757
Cough continues to be one of the top reasons why patients seek medical attention from health care providers. The prescription… 
2010
2010
Identification of Two Novel Metabolites of SCH 486757, a Nociceptin/Orphanin FQ Peptide Receptor Agonist, in Humans
The study of human metabolism of endo-8[bis(2-chlorophenyl)methyl]-3-(2-pyrimidinyl)-8-azabicyclo[3.2.1]octan-3-ol (SCH 486757… 
2010
2010
Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models.
2009
2009
The Efficacy of a NOP1 Agonist (SCH486757) in Subacute Cough
Currently, opiates are widely used as antitussives but have substantial side effects. Recently, it has been proposed that NOP1… 
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