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NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A.
TLDR
This research presents a meta-analyses of the immune system’s response to exposure to radiation and shows clear patterns of decline in the immune systems of men and women aged 65 and over. Expand
Androgen-mediated development in male rat offspring exposed to flutamide in utero: permanence and correlation of early postnatal changes in anogenital distance and nipple retention with malformations
TLDR
The data suggest that flutamide-mediated changes in AGD and nipple retention are not sensitive predictors of altered T-mediated development, and that proper development of these tissues may require both androgens. Expand
Male Reproductive Tract Lesions at 6, 12, and 18 Months of Age Following in Utero Exposure to Di(n-butyl) Phthalate
TLDR
Lower AGD and areolae retention were found to be permanent changes following in utero exposure to 500 mg/kg/day of DBP, and testicular dysgenesis, a lesion of proliferating LCs and aberrant tubules that has not been previously described in DBP-exposed testes was diagnosed. Expand
Effects of in utero exposure to linuron on androgen-dependent reproductive development in the male Crl:CD(SD)BR rat.
TLDR
In utero exposure to linuron preferentially impairs testosterone-mediated, rather than DHT- mediated, reproductive development, and this effect is distinctly different from the effects induced by flutamide, an AR antagonist that shares structural similarities with linuron. Expand
Modulation of mammary gland development in prepubertal male rats exposed to genistein and methoxychlor.
TLDR
The results indicated that the mammary glands of juvenile male rather than juvenile female rats may be more sensitive to certain endocrine-active compounds and that high levels of phytoestrogens have the potential to alter the toxicological behaviors of other hormone mimics. Expand
Antiproliferative and apoptotic effects of tocopherols and tocotrienols on preneoplastic and neoplastic mouse mammary epithelial cells.
TLDR
Comparative effects of tocopherols and tocotrienols on preneoplastic, neoplastic and highly malignant mouse mammary epithelial cell growth and viability in vitro showed that CL-S1, -SA, and +SA cells preferentially accumulate tocotrianols as compared with tocopHerols, and this may partially explain why tocotianols display greater biopotency than tocop herols. Expand
Antiproliferative and Apoptotic Effects of Tocopherols and Tocotrienols on Preneoplastic and Neoplastic Mouse Mammary Epithelial Cells
TLDR
Comparative effects of tocopherols and tocotrienols on preneoplastic, neoplastic and highly malignant mouse mammary epithelial cell growth and viability in vitro showed that CL-S1, -SA, and +SA cells preferentially accumulate tocotrianols as compared with tocopHerols, and this may partially explain why tocotianols display greater biopotency than tocop herols. Expand
Antiproliferative and apoptotic effects of tocopherols and tocotrienols on normal mouse mammary epithelial cells
TLDR
Findings suggest that the highly biopotent γ- and δ-tocotrienol isoforms may play a physiological role in modulating normal mammary gland growth, function, and remodeling. Expand
Endocrine Active Agents: Implications of Adverse and Non-Adverse Changes
TLDR
The advent of multigeneration reproduction studies as the definitive studies for the assessment of the dose-response relationships and risk assessment for endocrine disruptors has shown that current testing protocols may be inadequate to reliably detect the adverse effects of concern as only 1 adult/sex/litter is examined. Expand
Altered gene expression during rat Wolffian duct development in response to in utero exposure to the antiandrogen linuron.
TLDR
In the fetal testis, exposure to linuron did not result in reduced mRNA expression of the AR or that of several steroidogenic enzymes, supporting the hypothesis that linuron does not reduce fetal testosterone production, and changes in epididymal gene expression suggestive of altered paracrine interactions between the mesenchyme and epithelial cells during development. Expand
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