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SC 58236

Known as: SC-58236, SC58236 
National Institutes of Health

Papers overview

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2011
2011
Renal protective effect of chronic inhibition of COX-2 with SC-58236 in streptozotocin-diabetic rats.
The induction of renal cyclooxygenase-2 (COX-2) in diabetes has been implicated in the renal functional and structural changes in… 
Highly Cited
2007
Highly Cited
2007
Overexpression of cyclooxygenase-2 predisposes to podocyte injury.
Increased podocyte cyclooxygenase-2 (COX-2) expression is seen in rats after renal ablation and Thy-1 nephritis and in cultured… 
2007
2007
A selective cyclooxygenase-2 inhibitor decreases transforming growth factor-beta1 synthesis and matrix production in human peritoneal mesothelial cells.
High glucose concentration, which provides the chief driving force in peritoneal dialysis, has been considered to be an important… 
2006
2006
The neuronal excitability time-dependently changes after lipopolysaccharide administration in mice: Possible role of cyclooxygenase-2 induction
2006
2006
Peripheral inflammation modifies the effect of intrathecal IL-1β on spinal PGE2 production mainly through cyclooxygenase-2 activity. A spinal microdialysis study in freely moving rats
2005
2005
Expression of Mediators of Renal Injury in the Remnant Kidney of ROP Mice Is Attenuated by Cyclooxygenase-2 Inhibition
To investigate the effects of cyclooxygenase-2 (COX-2) inhibition on renal injury of mice, ROP mice were subjected to subtotal… 
2004
2004
Effect of COX-1/COX-2 Inhibition versus Selective COX-2 Inhibition on Coronary Vasodilator Responses to Arachidonic Acid and Acetylcholine
The effect of a nonselective COX-1/COX-2 inhibitor, naproxen, was compared with a COX-2-selective inhibitor (SC-58236) on… 
2003
2003
Variable antipyretic effect of SC-58236, a selective cyclooxygenase (COX)-2 inhibitor, in rats.
Fever is the most common body temperature (Tb) change accompanied to inflammation [1]. It has been reported that increased… 
2002
2002
Effect of misoprostol and indomethacin on cyclooxygenase induction and eicosanoid production in carrageenan-induced air pouch inflammation in rats.
2002
2002
Prostaglandins that increase renin production in response to ACE inhibition are not derived from cyclooxygenase-1.
It is well known that nonselective, nonsteroidal anti-inflammatory drugs inhibit renal renin production. Our previous studies… 
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