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SC 558

Known as: SC-558 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2018
02419962018

Related topics

Related topics

1 relation

Broader (1)

Pyrazoles

Related mentions per year

Related mentions per year

1950-2018
1960198020002020
SC 558
Pyrazoles

Papers overview

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2012
2012
Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2.
New pyrazole and pyrazoline derivatives have been synthesized and their ability to inhibit ovine COX-1/COX-2 isozymes was… (More)
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2011
2011
Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study.
New arylhydrazone derivatives and a series of 1,5-diphenyl pyrazoles were designed and synthesized from 1-(4-chlorophenyl)-4,4,4… (More)
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2011
2011
Synthesis, anti-inflammatory activity and COX-1/COX-2 inhibition of novel substituted cyclic imides. Part 1: Molecular docking study.
A group of cyclic imides (1-13) was designed for evaluation as selective COX-2 inhibitors and investigated in vivo for their anti… (More)
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2010
2010
Molecular basis of cyclooxygenase enzymes (COXs) selective inhibition.
The widely used nonsteroidal anti-inflammatory drugs block the cyclooxygenase enzymes (COXs) and are clinically used for the… (More)
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2006
2006
Ligand Coordinate Analysis of SC-558 from the Active Site to the Surface of COX-2: A Molecular Dynamics Study
We have performed a ligand coordinate analysis to monitor the movement of the inhibitor SC-558 from the active site of the COX-2… (More)
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2002
2002
Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models.
In the present study we have investigated whether pharmacophore models may account for the activity and selectivity of the known… (More)
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2002
2002
Inhibitory mode of 1,5-diarylpyrazole derivatives against cyclooxygenase-2 and cyclooxygenase-1: molecular docking and 3D QSAR analyses.
The Lamarckian genetic algorithm of AutoDock 3.0 has been employed to dock 40 1,5-diarylpyrazole class compounds into the active… (More)
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2002
2002
Computer-aided design of selective COX-2 inhibitors: comparative molecular field analysis, comparative molecular similarity indices analysis, and docking studies of some 1,2-diarylimidazole…
Comparative molecular field analysis and comparative molecular similarity indices analysis were performed on 114 analogues of 1,2… (More)
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2001
2001
Three-dimensional quantitative structure-activity relationships of cyclo-oxygenase-2 (COX-2) inhibitors: a comparative molecular field analysis.
The three-dimensional quantitative structure-activity relationship (3D-QSAR) approach using comparative molecular field analysis… (More)
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Highly Cited
1996
Highly Cited
1996
Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
PROSTAGLANDINSand glucocorticoids are potent mediators of inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs) exert… (More)
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