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SC 558

Known as: SC-558 
National Institutes of Health

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Related topics

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Broader (1)

Pyrazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
New pyrazole derivatives: Synthesis, anti-inflammatory activity, cycloxygenase inhibition assay and evaluation of mPGES.
Highly Cited
2016
Highly Cited
2016
Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibition activities and molecular docking study of pyrazoline derivatives.
Highly Cited
2015
Highly Cited
2015
Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: anti-inflammatory and analgesic activities.
2013
2013
Molecular design, synthesis and biological evaluation of cyclic imides bearing benzenesulfonamide fragment as potential COX-2 inhibitors. Part 2.
Highly Cited
2012
Highly Cited
2012
Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2.
Highly Cited
2011
Highly Cited
2011
Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study.
Highly Cited
2011
Highly Cited
2011
Synthesis, anti-inflammatory activity and COX-1/COX-2 inhibition of novel substituted cyclic imides. Part 1: Molecular docking study.
Highly Cited
2010
Highly Cited
2010
Molecular basis of cyclooxygenase enzymes (COXs) selective inhibition
The widely used nonsteroidal anti-inflammatory drugs block the cyclooxygenase enzymes (COXs) and are clinically used for the… 
Highly Cited
2002
Highly Cited
2002
Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models.
In the present study we have investigated whether pharmacophore models may account for the activity and selectivity of the known… 
Highly Cited
1996
Highly Cited
1996
Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
PROSTAGLANDINSand glucocorticoids are potent mediators of inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs) exert… 
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