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SC 558
Known as:
SC-558
National Institutes of Health
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Pyrazoles
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
New pyrazole derivatives: Synthesis, anti-inflammatory activity, cycloxygenase inhibition assay and evaluation of mPGES.
G. S. Hassan
,
Doaa E Abdel Rahman
,
Esraa A Abdelmajeed
,
R. H. Refaey
,
M. Alaraby Salem
,
Y. M. Nissan
European journal of medicinal chemistry
2019
Corpus ID: 89618571
Highly Cited
2016
Highly Cited
2016
Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibition activities and molecular docking study of pyrazoline derivatives.
M. Abdel-Sayed
,
S. M. Bayomi
,
+4 authors
A. Abdel-Aziz
Bioorganic & medicinal chemistry
2016
Corpus ID: 29053453
Highly Cited
2015
Highly Cited
2015
Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: anti-inflammatory and analgesic activities.
A. Alanazi
,
A. El-Azab
,
+4 authors
A. Abdel-Aziz
European journal of medicinal chemistry
2015
Corpus ID: 36861008
2013
2013
Molecular design, synthesis and biological evaluation of cyclic imides bearing benzenesulfonamide fragment as potential COX-2 inhibitors. Part 2.
Ibrahim A. Al-Suwaidan
,
A. Alanazi
,
+5 authors
A. Abdel-Aziz
Bioorganic & medicinal chemistry letters
2013
Corpus ID: 8904707
Highly Cited
2012
Highly Cited
2012
Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2.
M. A. El-Sayed
,
Naglaa I. Abdel-Aziz
,
A. Abdel-Aziz
,
A. El-Azab
,
K. Eltahir
Bioorganic & medicinal chemistry
2012
Corpus ID: 25468399
Highly Cited
2011
Highly Cited
2011
Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study.
M. A. El-Sayed
,
Naglaa I. Abdel-Aziz
,
A. Abdel-Aziz
,
A. El-Azab
,
Y. Asiri
,
K. Eltahir
Bioorganic & medicinal chemistry
2011
Corpus ID: 44331109
Highly Cited
2011
Highly Cited
2011
Synthesis, anti-inflammatory activity and COX-1/COX-2 inhibition of novel substituted cyclic imides. Part 1: Molecular docking study.
A. Abdel-Aziz
,
K. Eltahir
,
Y. Asiri
European journal of medicinal chemistry
2011
Corpus ID: 22374992
Highly Cited
2010
Highly Cited
2010
Molecular basis of cyclooxygenase enzymes (COXs) selective inhibition
V. Limongelli
,
M. Bonomi
,
+4 authors
M. Parrinello
Proceedings of the National Academy of Sciences
2010
Corpus ID: 40468251
The widely used nonsteroidal anti-inflammatory drugs block the cyclooxygenase enzymes (COXs) and are clinically used for the…
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Highly Cited
2002
Highly Cited
2002
Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models.
A. Palomer
,
F. Cabré
,
+7 authors
A. Espinosa
Journal of medicinal chemistry
2002
Corpus ID: 3078246
In the present study we have investigated whether pharmacophore models may account for the activity and selectivity of the known…
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Highly Cited
1996
Highly Cited
1996
Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
R. Kurumbail
,
A. Stevens
,
+9 authors
W. Stallings
Nature
1996
Corpus ID: 4326310
PROSTAGLANDINSand glucocorticoids are potent mediators of inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs) exert…
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