SC 558

Known as: SC-558 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1996-2018
02419962018

Papers overview

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2012
2012
New pyrazole and pyrazoline derivatives have been synthesized and their ability to inhibit ovine COX-1/COX-2 isozymes was… (More)
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2011
2011
New arylhydrazone derivatives and a series of 1,5-diphenyl pyrazoles were designed and synthesized from 1-(4-chlorophenyl)-4,4,4… (More)
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2011
2011
A group of cyclic imides (1-13) was designed for evaluation as selective COX-2 inhibitors and investigated in vivo for their anti… (More)
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2010
2010
The widely used nonsteroidal anti-inflammatory drugs block the cyclooxygenase enzymes (COXs) and are clinically used for the… (More)
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2006
2006
We have performed a ligand coordinate analysis to monitor the movement of the inhibitor SC-558 from the active site of the COX-2… (More)
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2002
2002
In the present study we have investigated whether pharmacophore models may account for the activity and selectivity of the known… (More)
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2002
2002
The Lamarckian genetic algorithm of AutoDock 3.0 has been employed to dock 40 1,5-diarylpyrazole class compounds into the active… (More)
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2002
2002
Comparative molecular field analysis and comparative molecular similarity indices analysis were performed on 114 analogues of 1,2… (More)
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2001
2001
The three-dimensional quantitative structure-activity relationship (3D-QSAR) approach using comparative molecular field analysis… (More)
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Highly Cited
1996
Highly Cited
1996
PROSTAGLANDINSand glucocorticoids are potent mediators of inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs) exert… (More)
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