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SC 558

Known as: SC-558 
 
National Institutes of Health

Papers overview

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2016
2016
Design, synthesis and pharmacological activities of a group of 1,3,5-trisubstituted pyrazolines were reported. The chemical… Expand
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Highly Cited
2015
Highly Cited
2015
A group of 30 cyclic imides (1-10a-c) was designed for evaluation as a selective COX-2 inhibitor and investigated in vivo for… Expand
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2013
2013
A group of cyclic imides (1-10) was designed for evaluation as a selective COX-2 inhibitors and investigated in vivo for their… Expand
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2012
2012
New pyrazole and pyrazoline derivatives have been synthesized and their ability to inhibit ovine COX-1/COX-2 isozymes was… Expand
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Highly Cited
2011
Highly Cited
2011
New arylhydrazone derivatives and a series of 1,5-diphenyl pyrazoles were designed and synthesized from 1-(4-chlorophenyl)-4,4,4… Expand
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2011
2011
A group of cyclic imides (1-13) was designed for evaluation as selective COX-2 inhibitors and investigated in vivo for their anti… Expand
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Highly Cited
2010
Highly Cited
2010
The widely used nonsteroidal anti-inflammatory drugs block the cyclooxygenase enzymes (COXs) and are clinically used for the… Expand
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2006
2006
We have performed a ligand coordinate analysis to monitor the movement of the inhibitor SC-558 from the active site of the COX-2… Expand
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Highly Cited
2002
Highly Cited
2002
In the present study we have investigated whether pharmacophore models may account for the activity and selectivity of the known… Expand
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Highly Cited
1996
Highly Cited
1996
PROSTAGLANDINSand glucocorticoids are potent mediators of inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs) exert… Expand
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