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SC 558

Known as: SC-558 
 
National Institutes of Health

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1 relation

Broader (1)

Pyrazoles

Papers overview

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2016
2016
Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibition activities and molecular docking study of pyrazoline derivatives.
Design, synthesis and pharmacological activities of a group of 1,3,5-trisubstituted pyrazolines were reported. The chemical… Expand
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Highly Cited
2015
Highly Cited
2015
Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: anti-inflammatory and analgesic activities.
A group of 30 cyclic imides (1-10a-c) was designed for evaluation as a selective COX-2 inhibitor and investigated in vivo for… Expand
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2013
2013
Molecular design, synthesis and biological evaluation of cyclic imides bearing benzenesulfonamide fragment as potential COX-2 inhibitors. Part 2.
A group of cyclic imides (1-10) was designed for evaluation as a selective COX-2 inhibitors and investigated in vivo for their… Expand
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2012
2012
Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2.
New pyrazole and pyrazoline derivatives have been synthesized and their ability to inhibit ovine COX-1/COX-2 isozymes was… Expand
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Highly Cited
2011
Highly Cited
2011
Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study.
New arylhydrazone derivatives and a series of 1,5-diphenyl pyrazoles were designed and synthesized from 1-(4-chlorophenyl)-4,4,4… Expand
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2011
2011
Synthesis, anti-inflammatory activity and COX-1/COX-2 inhibition of novel substituted cyclic imides. Part 1: Molecular docking study.
A group of cyclic imides (1-13) was designed for evaluation as selective COX-2 inhibitors and investigated in vivo for their anti… Expand
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Highly Cited
2010
Highly Cited
2010
Molecular basis of cyclooxygenase enzymes (COXs) selective inhibition
The widely used nonsteroidal anti-inflammatory drugs block the cyclooxygenase enzymes (COXs) and are clinically used for the… Expand
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2006
2006
Ligand Coordinate Analysis of SC-558 from the Active Site to the Surface of COX-2: A Molecular Dynamics Study
We have performed a ligand coordinate analysis to monitor the movement of the inhibitor SC-558 from the active site of the COX-2… Expand
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Highly Cited
2002
Highly Cited
2002
Identification of novel cyclooxygenase-2 selective inhibitors using pharmacophore models.
In the present study we have investigated whether pharmacophore models may account for the activity and selectivity of the known… Expand
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Highly Cited
1996
Highly Cited
1996
Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents
PROSTAGLANDINSand glucocorticoids are potent mediators of inflammation. Non-steroidal anti-inflammatory drugs (NSAIDs) exert… Expand
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