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SC 558

Known as: SC-558 
National Institutes of Health

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1 relation

Broader (1)

Pyrazoles

Papers overview

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2011
2011
Virtual screening of 2,3-disubstituted-4(3H)-quinazolinones possessing benzenesulfonamide moiety for COX-2 inhibitor
COX inhibitors which selectively inhibits the inducible COX-2 is an oenzyme that causes inflammation. They are clinically… 
2009
2009
A new method for in-silico drug screening and similarity search using molecular dynamics maximum volume overlap (MD-MVO) method.
2009
2009
Analyzing the Interaction of Andrographolide and Neoandrographolide, Diterpenoid Compounds From Andrographis Paniculata (Burm.F) Nees, to Cyclooxygenase-2 Enzyme by Docking Simulation
Cyclooxygenase (COX), an enzyme involved in the conversion of arachidonic acid to prostaglandins, exists in two isoforms, which… 
2003
2003
Computer-Aided Design of Selective COX-2 Inhibitors: Molecular Docking of Structurally Diverse Cyclooxygenase-2 Inhibitors using FlexX Method
Motivation. Three-dimensional structures of pharmacologically important macromolecules offer a route to the discovery of new… 
Highly Cited
2002
Highly Cited
2002
Inhibitory mode of 1,5-diarylpyrazole derivatives against cyclooxygenase-2 and cyclooxygenase-1: molecular docking and 3D QSAR analyses.
The Lamarckian genetic algorithm of AutoDock 3.0 has been employed to dock 40 1,5-diarylpyrazole class compounds into the active… 
Highly Cited
2002
Highly Cited
2002
Computer-aided design of selective COX-2 inhibitors: comparative molecular field analysis, comparative molecular similarity indices analysis, and docking studies of some 1,2-diarylimidazole…
Comparative molecular field analysis and comparative molecular similarity indices analysis were performed on 114 analogues of 1,2… 
1997
1997
Comparative molecular modeling study of the three-dimensional structures of prostaglandin endoperoxide H2 synthase 1 and 2 (COX-1 and COX-2).
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