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SC 52458

Known as: SC-52458 
National Institutes of Health

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forasartan

Papers overview

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1997
1997
Up-regulation of angiotensin type 2 receptor mRNA by angiotensin II in rat cortical cells.
The present experiment demonstrates that the exposure of angiotensin II (AII) produced an up-regulation of the AT2 receptor mRNA… 
1997
1997
SC-52458, an orally active angiotensin II-receptor antagonist: inhibition of blood pressure response to angiotensin II challenges and pharmacokinetics in normal volunteers.
This study was designed to assess in normal volunteers the potency, efficacy, and tolerability of the new nonpeptidic, orally… 
1997
1997
Effects of SC-52458, an angiotensin AT1 receptor antagonist, in the dog.
1996
1996
Effects of SC-52458, a new nonpeptide angiotensin II receptor antagonist, on increase in cytoplasmic Ca2+ concentrations and contraction induced by angiotensin II and K(+)-depolarization in guinea…
1993
1993
Pharmacology of SC‐52458, an Orally Active, Nonpeptide Angiotensin AT1 Receptor Antagonist
Summary We describe the pharmacologic properties of SC-52458, 5-[(3,5-dibutyl-1H-1,2,4-triazol-1-yl)methyl]-2-[2-(1H-tetrazol-5… 
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