SB 743921

Known as: SB-743921, SB743921 
A synthetic small molecule with potential antineoplastic properties. SB-743921 selectively inhibits kinesin spindle protein (KSP), an important… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2006-2015
02420062015

Papers overview

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2015
2015
Inhibition of the cell mitotic pathway may provide a novel means for therapeutic intervention in chronic myeloid leukemia (CML… (More)
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2015
2015
The kinesin spindle protein (KSP) is a mitotic protein essential for cell cycle control and motility. SB-743921 (hereafter SB-921… (More)
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2015
2015
SB743921 is a potent inhibitor of the spindle protein kinesin and is being investigated in ongoing clinical trials for the… (More)
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2014
2014
The mitotic kinesin KIF11 (also called Eg5) plays critical roles in spindle functions. Although a number of small-molecule… (More)
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2013
2013
Development of drug resistance during cancer chemotherapy is one of the major causes of chemotherapeutic failure for the majority… (More)
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2013
2013
Talapatra et al. elucidated the molecular basis of resistance by characterizing the binding interactions between Eg5 and the… (More)
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2013
2013
The mitotic kinesin Eg5 is critical for the assembly of the mitotic spindle and is a promising chemotherapy target. Previously… (More)
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2010
2010
To determine the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), safety, pharmacokinetics, and pharmacodynamics of SB… (More)
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2009
2009
8578 Background: KSP is a mitotic kinesin essential for cell cycle progression. SB-743921 (SB-921), a selective KSP inhibitor… (More)
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2006
2006
2000 Background: SB-743921, a potent and selective inhibitor of KSP (Ki =100 pM; >40,000-fold selectivity vs other kinesins… (More)
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