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SB 743921

Known as: SB-743921, SB743921 
A synthetic small molecule with potential antineoplastic properties. SB-743921 selectively inhibits kinesin spindle protein (KSP), an important… 
National Institutes of Health

Papers overview

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2019
2019
Aims Kinesin family member 11 (Kif11) is a member of the kinesin family motor proteins, which is associated with spindle… 
2016
2016
Kinesin spindle protein (KSP) is a microtubule-associated motor protein that is specifically expressed by mitosis cells. It is… 
2015
2015
Abstract Inhibition of the cell mitotic pathway may provide a novel means for therapeutic intervention in chronic myeloid… 
2013
2013
Development of drug resistance during cancer chemotherapy is one of the major causes of chemotherapeutic failure for the majority… 
2013
2013
The mitotic kinesin Eg5 is critical for the assembly of the mitotic spindle and is a promising chemotherapy target. Previously… 
2012
2012
The complex between the motor protein Eg5 and the phase II clinical candidate ispinesib provides insights into the mechanism of… 
Highly Cited
2010
Highly Cited
2010
PurposeTo determine the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), safety, pharmacokinetics, and… 
2006
2006
2000 Background: SB-743921, a potent and selective inhibitor of KSP (Ki =100 pM; >40,000-fold selectivity vs other kinesins… 
2006
2006
B11 Discovery and development of drugs that target mitosis continues to be an active and important area of cancer drug research…