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SB 743921

Known as: SB-743921, SB743921 
A synthetic small molecule with potential antineoplastic properties. SB-743921 selectively inhibits kinesin spindle protein (KSP), an important… Expand
National Institutes of Health

Papers overview

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2019
2019
Aims Kinesin family member 11 (Kif11) is a member of the kinesin family motor proteins, which is associated with spindle… Expand
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2015
2015
The kinesin spindle protein (KSP) is a mitotic protein essential for cell cycle control and motility. SB-743921 (hereafter SB-921… Expand
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2015
2015
Abstract Inhibition of the cell mitotic pathway may provide a novel means for therapeutic intervention in chronic myeloid… Expand
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2014
2014
The mitotic kinesin KIF11 (also called Eg5) plays critical roles in spindle functions. Although a number of small-molecule… Expand
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2013
2013
Development of drug resistance during cancer chemotherapy is one of the major causes of chemotherapeutic failure for the majority… Expand
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2012
2012
The human kinesin Eg5 is responsible for bipolar spindle formation during early mitosis. Inhibition of Eg5 triggers the formation… Expand
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2010
2010
PurposeTo determine the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), safety, pharmacokinetics, and… Expand
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2009
2009
8578 Background: KSP is a mitotic kinesin essential for cell cycle progression. SB-743921 (SB-921), a selective KSP inhibitor… Expand
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2006
2006
B11 Discovery and development of drugs that target mitosis continues to be an active and important area of cancer drug research… Expand
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2005
2005
2000 Background: SB-743921, a potent and selective inhibitor of KSP (Ki =100 pM; >40,000-fold selectivity vs other kinesins… Expand
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